Results 101 to 110 of about 3,658,908 (303)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Practical Prognostics Method Based on Stepwise Linear Approximation of a Nonlinear Degradation Model

Applied Sciences
Prognostics aims to predict the remaining useful life (RUL) of an in-service system based on its degradation data. Existing methods, such as artificial neural networks (ANNs) and their variations, often face challenges in real-world applications due to ...
Dawn An
doaj   +1 more source

The pattern of healthy diets and zero hunger among households in South-West Nigeria: application of linear approximation to quadratic almost ideal demand system. [PDF]

Front Public Health, 2023
Ogunleke AO, Olawuyi SO, Ijila OJ.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

fastSW: Efficient Piecewise Linear Approximation of Quaternion-Based Orientation Sensor Signals for Motion Capturing with Wearable IMUs. [PDF]

Sensors (Basel), 2021
Grützmacher F, Kempfle J, Van Laerhoven K, Haubelt C.   +3 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Privacy-Preserving Linear and Nonlinear Approximation via Linear Programming [PDF]

, 2011
We propose a novel privacy-preserving random kernel approximation based on a data matrix A ? Rm n whose rows are divided into privately owned blocks.
Mangasarian, Olvi, Fung, Glenn
core  

Day-Ahead Electricity Price Forecasting in the Contemporary Italian Market

IEEE Access
In competitive electricity markets, prices are determined by the collective behaviour of suppliers and consumers. Hence, these systems rely on the balance between supply and demand, and sudden changes in the underlying conditions can lead to significant ...
Francesco Moraglio, Carlo S. Ragusa
doaj   +1 more source

Time-frequency doubly selective channel estimation based on compressed sensing

上海师范大学学报. 自然科学版, 2017
In this paper,considering time-frequency doubly selective channel,we utilize the channel's time correlation that the channel coefficientscorresponding tothe neighboring instants have a strong correlation.And we present a linear approximation method,which
Tu Yuliang, Gui Lin, Qin Qibo, Luo Hanwen   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source