Results 101 to 110 of about 172,072 (313)

Continuous and Discontinuous Linear Approximation of the Window Spectrum by Least Squares Method [PDF]

, 2011
Józef Borkowski
openalex   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Fast evaluation of nonlinear functions using FPGAs [PDF]

Advances in Radio Science, 2008
The paper presents a novel method of evaluating the square root function in FPGA. The method uses a linear approximation subsystem with a reduced size of a look-up table. The reduction in the size of the lookup table is twofold.
S. Lachowicz, H.-J. Pfleiderer
doaj  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Prediction of PM10 Time Series at Industrial Area Through an Improved Local Linear Approximation Method

, 2020
Nor Zila, Abd Hamid, A Ul-Saufie, A Yahaya, N Ramli, N Rosaida, H, A Ul-Saufie, A Yahaya, N Ramli, H &hamid, A Ul-Saufie, A Yahaya, N Ramli, H Hamid, H Yu, Y Lin, B Sivakumar, Y Kuo, W Zaim, N Hamid   +20 more
openalex   +2 more sources

Symplectic Partitioned Runge‐Kutta Methods for High‐Order Approximation in Linear‐Quadratic Optimal Control of Hamiltonian Systems [PDF]

, 2021
Markus Herrmann-Wicklmayr, Kathrin Flaßkamp   +1 more
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On the existence of optimal affine methods for approximating linear functionals

Journal of Complexity, 1986
Let F be a set in a linear space and S, \(x_ 1,...,x_ n\) functionals on F, \(f\in F\). To construct an optimal method for approximation S(f) means to find a function \(\theta_ 0\) minimizing \(\sup_{f\in F}| S(f)-\theta (x_ 1(f),...,x_ n(f))|\) over the set of all real valued functions \(\theta\).
openaire   +2 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

A High-Precision, All-Rectangle-Based Method Linearly Concave Hydropower Output in Long-Term Reservoir Operation

Energies
The nonlinearity and non-convexity of the hydropower output function (HOF) make it very challenging to search for the optimal solution to the hydropower scheduling problem, which, however, can be more easily solved with consistency by mathematical ...
Hao Zheng, Yan Huang, Yongqiang Wang, Feixiang Hou, Yong Xu, Cheng Chen, Suzhen Feng, Jinwen Wang   +7 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source