Results 141 to 150 of about 5,134,174 (310)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

An active linear algebra library using delayed evaluation

, 2008
Francis P Russell, Michael R Mellor, Paul H J Kelly and Olav Beckmann Department of Computing Imperial College London 180 Queen's Gate, London SW7 2AZ, UK ABSTRACT Active libraries can be defined as libraries which play an active part in the ...
And Runtime Code
core  

Effect of varying soil conditions on soil-structure interaction in berthing structures: A case study using modelling approach

Advances in Civil and Architectural Engineering
The substructure of a berthing structure with a deep draft presents significant financial challenges. This research offers valuable perspectives on minimizing substructure expenses for a berthing structure by leveraging the Indian Standard (IS) code for ...
Namratha Sasikumar, Ilamainathan Natarajan, Joanna Philip Saratha   +2 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

R code of the Efficient Linear Method (ELM)

, 2014
R code of the Efficient Linear Method (ELM) for constructing QSAR/QSPR models that is readily interpretable.
Veda Prachayasittikul (676526), Watshara Shoombuatong (453384), Virapong Prachayasittikul (13700), Chanin Nantasenamat (676525)   +3 more
core   +1 more source

GEOMETRIC CONSTRUCTION CODES OF HAMMING DISTANCE-8

Electrica, 2008
A new high rate binary linear block code construction technique, named as Geometric Construction (GC) codes, was proposed recently [1]. It generates all the even full information rate (optimal) Hamming distance – 4 codes.
Gökmen Altay
doaj   +2 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

MIMO Assisted Space-Code-Division Multiple-Access: Linear Detectors and Performance over Multipath Fading Channels

, 2006
In this contribution we propose and investigate a multiple-input multiple-output space-division, code-division multiple-access (MIMO SCDMA) scheme. The main objective is to improve the capacity of the existing DS-CDMA systems, for example, for supporting
Yang, L.-L.
core   +1 more source