Results 141 to 150 of about 7,931,944 (349)
Studies and measurements of linear coupling and nonlinearities in hadron circular accelerators [PDF]
, 2006 In this thesis a beam-based method has been developed to measure the strength and the polarity of corrector magnets (skew quadrupoles and sextupoles) in circular accelerators.
Franchi, Andrea
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Matlab code for the Riccati solution to linear quadratic model
This program calculates through Riccati iterations the feedback laws of a quadratic problem with linear constraints.
Thomas Sargent
core
Fast iterative solvers for geomechanics in a commercial FE code
, 2009 There is a pressing need to improve the feasibility of three-dimensional finite element (FE) methods applied to many problems in civil engineering. This is particularly the case for static analyses in geotechnical engineering: ideally, models would be 3D,
Augarde, C +8 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Classification of binary systematic codes of small defect
Le Matematiche, 2014 In this paper non-trivial non-linear binary systematic AMDS codes are classified in terms of their weight distributions, employing only elementary techniques.
Alberto Ravagnani
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Advanced Virtual Accelerator Software: A linear accelerator simulation code
Physical Review Accelerators and BeamsThe Advanced Virtual Accelerator Software (avas) has been developed to simulate beam transport processes in high-intensity linear accelerators and has been used in the China Initiative Accelerator Driven System (CiADS) project.
Chao Jin +11 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source