Results 41 to 50 of about 791,497 (327)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Analysis and Application of A One-Layer Neural Network for Solving Horizontal Linear Complementarity Problems [PDF]

International Journal of Computational Intelligence Systems, 2014
In this paper, we analyze the stability and convergence of a one-layer neural network proposed by Gao and Wang, which is designed to solve a class of horizontal linear complementarity problems. The globally asymptotical stability and globally exponential
Xingbao Gao, Jing Wang
doaj   +1 more source

A numerical method for parabolic complementarity problem

Electronic Research Archive, 2023
In this paper, we study the numerical solution of a parabolic complementarity problem which is a widely used model in many fields, such as option pricing, risk measures, etc.
Haiyan Song, Fei Sun
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Preconditioned Multisplitting and Schwarz Method for Linear Complementarity Problem

Journal of Applied Mathematics, 2014
The preconditioner presented by Hadjidimos et al. (2003) can improve on the convergence rate of the classical iterative methods to solve linear systems.
Cuiyu Liu, Chen-liang Li
doaj   +1 more source

Algorithm for calculating the problem of unilateral frictional contact with an increscent external load parameter

Structural Mechanics of Engineering Constructions and Buildings, 2023
The subject of the study is the contact interaction of deformable elements of linear complementarity problem (LCP). To solve the linear complementarity problem, the Lemke method with the introduction of an increasing parameter of external loading is used.
Alexander N. Popov, Alexander D. Lovtsov
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Algebraic multigrid preconditioners for two-phase flow in porous media with phase transitions

, 2018
Multiphase flow is a critical process in a wide range of applications, including oil and gas recovery, carbon sequestration, and contaminant remediation.
Bui, Quan M., Osei-Kuffuor, Daniel, Wang, Lu   +2 more
core   +1 more source

Sign-solvable linear complementarity problems

Linear Algebra and its Applications, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source