Results 71 to 80 of about 1,223,903 (308)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
On the Oscillation of the Generalized Food-Limited Equations with Delay
Aceh International Journal of Science and Technology, 2012 The objective of the paper is to find conditions for the oscillation of the food-limited equation. We established conditions for the oscillation of all solutions of the generalized foodlimited equation by transforming the equation to a non-linear delay ...
Bamaina M. Muhammad +2 more
doaj +3 more sources
Local estimates for modified Riccati equation in theory of half-linear differential equation
Electronic Journal of Qualitative Theory of Differential Equations, 2012 In this paper we study the half-linear differential equation \begin{equation*} \bigl(r(t)\Phi_p(x')\bigr)'+c(t)\Phi_p(x)=0, \end{equation*} where $\Phi_p(x)=|x|^{p-2}x$, $p>1$. Using modified Riccati technique and suitable local estimates for terms
Simona Fišnarová, Robert Marik
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Abstract and Applied Analysis, 2012 We investigate transformations of the modified Riccati differential equation and the obtained results we apply in the investigation of oscillatory properties of perturbed half-linear Euler differential equation.
Ondřej Došlý, Hana Funková
doaj +1 more source
A kind of non-zero sum mixed differential game of backward stochastic differential equation
Advances in Difference Equations, 2020 This paper is concerned with a non-zero sum mixed differential game problem described by a backward stochastic differential equation. Here the term “mixed” means that this game problem contains a deterministic control v1 $v_{1}$ of Player 1 and a random ...
Huanjun Zhang
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
An extension of A-stability to alternating direction implicit methods [PDF]
An alternating direction implicit (ADI) scheme was constructed by the method of approximate factorization. An A-stable linear multistep method (LMM) was used to integrate a model two-dimensional hyperbolic-parabolic partial differential equation ...
Beam, R. M., Warming, R. F.
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source