Results 71 to 80 of about 1,073,247 (330)
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
On the Oscillation of the Generalized Food-Limited Equations with Delay
Aceh International Journal of Science and Technology, 2012 The objective of the paper is to find conditions for the oscillation of the food-limited equation. We established conditions for the oscillation of all solutions of the generalized foodlimited equation by transforming the equation to a non-linear delay ...
Bamaina M. Muhammad +2 more
doaj +3 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Local estimates for modified Riccati equation in theory of half-linear differential equation
Electronic Journal of Qualitative Theory of Differential Equations, 2012 In this paper we study the half-linear differential equation \begin{equation*} \bigl(r(t)\Phi_p(x')\bigr)'+c(t)\Phi_p(x)=0, \end{equation*} where $\Phi_p(x)=|x|^{p-2}x$, $p>1$. Using modified Riccati technique and suitable local estimates for terms
Simona Fišnarová, Robert Marik
doaj +1 more source
A kind of non-zero sum mixed differential game of backward stochastic differential equation
Advances in Difference Equations, 2020 This paper is concerned with a non-zero sum mixed differential game problem described by a backward stochastic differential equation. Here the term “mixed” means that this game problem contains a deterministic control v1 $v_{1}$ of Player 1 and a random ...
Huanjun Zhang
doaj +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Shadowing for linear systems of differential equations [PDF]
Publicacions Matemàtiques, 1993 For a system of linear ordinary differential equations with constant coefficients a simple proof is given that hyperbolicity is equivalent to shadowing.
openaire +5 more sources
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
The linear difference-differential equation with linear coefficients [PDF]
Transactions of the American Mathematical Society, 1955 v(x) a known function, and a;, a', any numbers (real or complex) such that ainn O and a' l/amn is either nonreal or positive. This equation is a particular case of the general linear equation (see Wright [7]), where the coefficient au,^x+ac4 in (1.1) is replaced by a known function A,,(x), and also of the linear equation with asymptotically constant ...
openaire +2 more sources