Results 111 to 120 of about 111,184 (298)

Machine Learning‐Enhanced Ultrasensitive Immuno‐CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers

open access: yesAdvanced Science, EarlyView.
This work presents a CRISPR‐based, ultrasensitive multiplex protein detection array capable of simultaneously analyzing six plasma biomarkers associated with Alzheimer's disease (AD). By integrating antibody‐mediated signal transduction, recombinase polymerase amplification, and spatially encoded CRISPR‐Cas12a, the system achieves detection sensitivity
Liding Zhang   +9 more
wiley   +1 more source

The matrix form for weighted linear discriminant analysis and fractional linear discriminant analysis [PDF]

open access: yes, 2009
In this paper we will extend the recently proposed weighted linear discriminant analysis (W_LDA) and fraction-step linear discriminant analysis (F_LDA) from one dimension vector form to the case of two dimension matrix form, which are called weighted two
Xu, T., Liu, Wan-quan, Lu, C.
core  

Histogram of the Linear discriminant analysis. [PDF]

open access: yes, 2019
Histogram of the Linear discriminant analysis (LDA) coupled with effect size measurements (LEfSe) identified the most differentially abundant genera between the MN, MM and MD groups.
Shengping Wang (1519651)   +7 more
core   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

open access: yesAdvanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu   +11 more
wiley   +1 more source

A Multi Linear Discriminant Analysis Method Using a Subtraction Criteria

open access: yesپژوهش‌های ریاضی, 2017
Linear dimension reduction has been used in different application such as image processing and pattern recognition. All these data folds the original data to vectors and project them to an small dimensions.
m rezghi, amin rastegar
doaj  

Regularized complete linear discriminant analysis [PDF]

open access: yes, 2014
Fundamental Research Funds for the Central Universities [2011121010]Linear discriminant analysis (LDA) searches for a linear transformation that maximizes class separability in a reduced dimensional space, Because LDA requires the within-class scatter ...
Wu, Houyuan, Yang, Wuyi, 杨武夷
core  

Robust selection of variables in linear discriminant analysis [PDF]

open access: yes, 2007
Linear discriminant analysis, Variable selection, Wilks’ lambda, Minimum covariance discriminant, MCD,
Valentin Todorov, V. Todorov
core   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

open access: yesAdvanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu   +8 more
wiley   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

open access: yesAdvanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen   +9 more
wiley   +1 more source

Multigroup discriminant analysis using linear programming [PDF]

open access: yes, 1997
In this paper we introduce a non-parametric linear programming formulation for the general multigroup classification problem. Previous research using linear programming formulations has either been limited to the two-group case, or required complicated ...
Gochet, W.   +3 more
core  

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