Results 141 to 150 of about 250,607 (319)

Precise and coordinated gearshift control for AMT gearshift system equipped with two linear actuators

open access: yesMechanics & Industry
A type of automated manual transmission gearshift system that uses two linear actuators to perform gearshift events is presented. The shifting mechanism can be made simpler by using linear actuator to drive the shift fork directly. The mathematical model
Lin Shusen, Li Bo, Tang Min, Wang Libiao
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Research on current control strategy of overvoltage flexible suppression device based on cascaded linear-nonlinear active disturbance rejection controller

open access: yesAIP Advances
In order to improve the immunity and speed tracking performance of active inverters in resonant overvoltage flexible suppression under load variation, parameter perturbation, and other uncertainties, a current control strategy of a resonant overvoltage ...
Haichun Niu   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Robust control in presence of parametric uncertainties: Observer-based feedback controller design [PDF]

open access: yes, 2008
Chen   +19 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

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