Results 101 to 110 of about 3,132,689 (290)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Non Linear Modelling and Control of Unified Power Flow Controller [PDF]
E3S Web of ConferencesUnified Power Flow Controller is modeled as a non linear system in order to apply a non linear control technique for the improvement of power flow in a Single Machine Infinite Bus system.
Ravikumar N.V.A. +2 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Linear Instability of Planar Shear Banded Flow [PDF]
Physical Review Letters, 2005 We study the linear stability of planar shear banded flow with respect to perturbations with wavevector in the plane of the banding interface, within the non local Johnson Segalman model. We find that perturbations grow in time, over a range of wavevectors, rendering the interface linearly unstable.
openaire +5 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Stability of Two Axially Superposed Fluids of Different Viscosities between Two Rotating Cylinders
Journal of Applied Fluid Mechanics, 2016 The linear stability of two axially superposed immiscible fluids between two rotating coaxial cylinders is studied. The fluids are assumed to have equal density but different viscosities.
V. R. K. Raju
doaj
Linear Flows on $\kappa $-Solenoids
, 1999 Linear flows on inverse limits of tori are defined and it is shown that two linear flows on an inverse limit of tori are equivalent if and only if there is an automorphism of the inverse limit generating the equivalence.
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source