Results 101 to 110 of about 3,117,054 (342)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Relative Effects of Asymmetry and Wall Slip on the Stability of Plane Channel Flow
Fluids, 2017 The effect of wall velocity slip on the stability of a pressure-driven two-dimensional asymmetric channel flow is examined by considering Navier slip condition on the channel walls.
Sukhendu Ghosh
doaj +1 more source
Linear flow-velocity gradient chromatography-An efficient method for increasing the process efficiency of batch and continuous capture chromatography of proteins. [PDF]
Biotechnol Bioeng, 2021 Chen CS +3 more
europepmc +1 more source
Definition of a linear equivalent model for a non-linear system with impacts [PDF]
, 2012 Modal characteristics of non-linear system are typically studied through response to harmonic excitation and using various definitions of non-linear modes. However, few results are available for systems under broadband excitation.
BALMES, Etienne +2 more
core +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Non Linear Modelling and Control of Unified Power Flow Controller [PDF]
E3S Web of ConferencesUnified Power Flow Controller is modeled as a non linear system in order to apply a non linear control technique for the improvement of power flow in a Single Machine Infinite Bus system.
Ravikumar N.V.A. +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Stability of Two Axially Superposed Fluids of Different Viscosities between Two Rotating Cylinders
Journal of Applied Fluid Mechanics, 2016 The linear stability of two axially superposed immiscible fluids between two rotating coaxial cylinders is studied. The fluids are assumed to have equal density but different viscosities.
V. R. K. Raju
doaj