Results 111 to 120 of about 3,117,054 (342)
Linear stability analysis of shear flows with thermal effects
, 2022 Gabriel Yudi Ragni Hamada
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Linear Instability of Planar Shear Banded Flow [PDF]
Physical Review Letters, 2005 We study the linear stability of planar shear banded flow with respect to perturbations with wavevector in the plane of the banding interface, within the non local Johnson Segalman model. We find that perturbations grow in time, over a range of wavevectors, rendering the interface linearly unstable.
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Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Linear Flows on $\kappa $-Solenoids
, 1999 Linear flows on inverse limits of tori are defined and it is shown that two linear flows on an inverse limit of tori are equivalent if and only if there is an automorphism of the inverse limit generating the equivalence.
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Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
The Impact of Nonlinear Flow Regime on the Flow Rate in Fractal Fractures
FluidsGeometric properties of fractures, such as aperture and width, among others, significantly affect the fluid flow behaviors in fractured media. Previous studies have shown that fractures exhibit fractal properties.
Jianting Zhu
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Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source