Results 41 to 50 of about 114,855,941 (268)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Linear forms in the logarithms of three positive rational numbers [PDF]

Journal de théorie des nombres de Bordeaux, 1997
In this paper we prove a lower bound for the linear dependence of three positive rational numbers under certain weak linear independence conditions on the coefficients of the linear forms. Let Λ =
Bennett, Curtis D., Blass, Josef, Glass, A. M. W., Meronk, David B., Steiner, Ray P.   +4 more
openaire   +1 more source

Factorization of leading chiral logarithms in the pion form factors [PDF]

, 2013
In the recently proposed framework of hard pion chiral perturbation theory, the leading chiral logarithms are predicted to factorize with respect to the energy dependence in the chiral limit.
Procura, Massimiliano, Colangelo, Gilberto, Stucki, Ramon, Rothen, Lorena, Tarrús Castellà, J.   +4 more
core   +2 more sources

On the number of linear forms in logarithms

Journal of Number Theory, 2007
8 ...
openaire   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Solving elliptic Diophantine equations by estimating linear forms in elliptic logarithms [PDF]

, 1994
In order to compute all integer points on a Weierstraß equation for an elliptic curve E/Q, one may translate the linear relation between rational points on E into a linear form of elliptic logarithms.
Stroeker, R., Tzanakis, N (Nikos), R. J. Stroeker, N. Tzanakis, Stroeker, RJ (Roel), Tzanakis, N., R. Stroeker   +6 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

GUARANTEED PREDICTIVE ESTIMATION OF SOLUTIONS OF SYSTEMS OF DIFFERENTIAL EQUATIONS WITH THE GOMPERTZIAN DYNAMICS WITH OBSERVATIONS IN DISCRETE TIME MOMENTS

Міжнародний науково-технічний журнал "Проблеми керування та інформатики"
In this paper, we introduce a mathematical model of spreading information messages. Suppose, a community is influenced by one of n sources of information.
О.Г. Наконечний, П.М. Зінько, Т.П. Зінько, Ю.М. Шевчук   +3 more
doaj   +1 more source