Results 41 to 50 of about 92,871 (258)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Linear forms in the logarithms of three positive rational numbers [PDF]
Journal de théorie des nombres de Bordeaux, 1997 In this paper we prove a lower bound for the linear dependence of three positive rational numbers under certain weak linear independence conditions on the coefficients of the linear forms. Let Λ=b 2 logα 2 -b 1 logα 1 -b 3 logα 3 ≠0 with b 1 ,b 2 ,b 3 positive integers and α 1 ,α 2 ,α 3 positive multiplicatively independent rational numbers greater ...
Bennett, Curtis D. +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Primjena linearnih formi u logaritmima na rješavanje diofantskih jednadžbi [PDF]
, 2018 U ovom diplomskom radu, bavimo se primjenom linearnih formi u logaritmima na rješavanje diofantskih problema. Na početku rada iskazujemo osnovne pojmove i definicije koje su nam potrebne u nastavku rada.
Ilić, Marina
core +2 more sources
Logarithmic SUSY electroweak effects on four-fermion processes at TeV energies
, 2000 We compute the MSSM one-loop contributions to the asymptotic energy behaviour of fermion-antifermion pair production at future lepton-antilepton colliders. Besides the conventional logarithms of Renormalization Group origin, extra SUSY linear logarithmic
A. Blondel +31 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Discrete logarithms in curves over finite fields [PDF]
, 2007 A survey on algorithms for computing discrete logarithms in Jacobians of curves over finite ...
Andreas Enge +4 more
core +5 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Computing discrete logarithms in subfields of residue class rings [PDF]
, 2014 Recent breakthrough methods \cite{gggz,joux,bgjt} on computing discrete logarithms in small characteristic finite fields share an interesting feature in common with the earlier medium prime function field sieve method \cite{jl}.
Anand, Kumar Narayanan, Ming-deh Huang
core