Results 41 to 50 of about 114,595,259 (259)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Fibonacci and Lucas numbers close to Narayana's cows numbers
Researches in MathematicsIn this study, we find all Fibonacci and Lucas numbers which are close to Narayana's cows numbers. The main tools used in this work are lower bounds for linear forms in logarithms due to Matveev and Dujella-Pethö version of the Baker-Davenport reduction ...
A. Satapathy +3 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hamiltonian and Variational Linear Distributed Systems [PDF]
, 2002 We use the formalism of bilinear- and quadratic differential forms in order to study Hamiltonian and variational linear distributed systems. It was shown in [1] that a system described by ordinary linear constant-coefficient differential equations is ...
Rapisarda, P. +7 more
core +3 more sources
Linear Forms in Logarithms and Fibonacci Numbers [PDF]
, 2019 The main work included in these pages is from a paper co-written by myself and my brother, Simon Earp-Lynch, under the supervision of Omar Kihel, pertaining to Diophantine triples of Fibonacci numbers.
Earp-Lynch, Benjamin
core +1 more source
On a few Diophantine equations, in particular, Fermat's last theorem
International Journal of Mathematics and Mathematical Sciences, 2003 This is a survey on Diophantine equations, with the purpose being to give the flavour of some known results on the subject and to describe a few open problems.
C. Levesque
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source