Results 51 to 60 of about 53,772 (244)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Coincidences in generalized Lucas sequences [PDF]
, 2014 For an integer $k\geq 2$, let $(L_{n}^{(k)})_{n}$ be the $k-$generalized Lucas sequence which starts with $0,\ldots,0,2,1$ ($k$ terms) and each term afterwards is the sum of the $k$ preceding terms.
Bravo, Eric F. +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Primjena linearnih formi u logaritmima na rješavanje diofantskih jednadžbi [PDF]
, 2018 U ovom diplomskom radu, bavimo se primjenom linearnih formi u logaritmima na rješavanje diofantskih problema. Na početku rada iskazujemo osnovne pojmove i definicije koje su nam potrebne u nastavku rada.
Ilić, Marina
core +2 more sources
Euler's constant, q-logarithms, and formulas of Ramanujan and Gosper
, 2003 The aim of the paper is to relate computational and arithmetic questions about Euler's constant $\gamma$ with properties of the values of the $q$-logarithm function, with natural choice of $q$.
E. Catalan +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
$B_K$ using HYP-smeared staggered fermions in $N_f=2+1$ unquenched QCD
, 2010 We present results for kaon mixing parameter $B_K$ calculated using HYP-smeared improved staggered fermions on the MILC asqtad lattices. We use three lattice spacings ($a\approx 0.12$, $0.09$ and $0.06\;$fm), ten different valence quark masses ($m\approx
A. T. Lytle +24 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Discrete logarithms in curves over finite fields [PDF]
, 2007 A survey on algorithms for computing discrete logarithms in Jacobians of curves over finite ...
Andreas Enge +4 more
core +5 more sources