Results 61 to 70 of about 3,575 (254)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Integral zeroes of Krawtchouk polynomials [PDF]
, 2012 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.Krawtchouk polynomials appear in many various areas of mathematics starting from discrete mathematics (e.g., in coding theory), association schemes, and in ...
Alenezi, Ahmad M
core
Effective irrationality measures for quotients of logarithms of rational numbers
, 2015 We establish uniform irrationality measures for the quotients of the logarithms of two rational numbers which are very close to 1. Our proof is based on a refinement in the theory of linear forms in logarithms which goes back to a paper of ...
Bugeaud, Yann
core +1 more source
Linear forms in the logarithms of three positive rational numbers [PDF]
Journal de théorie des nombres de Bordeaux, 1997 In this paper we prove a lower bound for the linear dependence of three positive rational numbers under certain weak linear independence conditions on the coefficients of the linear forms. Let Λ =
Bennett, Curtis D. +4 more
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 1993 If (um)m∈N0 denotes a Lucas sequence, i.e. a binary integer recurrence sequence with initial values u0=0 and u1=1, then the equation kum=lun with k,l∈Z⧹{0} and max{m,n}≥5 can be valid only for finitely many Lucas sequences with coprime roots and finitely
Töpfer, Thomas
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source