Results 81 to 90 of about 118,435,286 (275)
On the equation $a(x^m-1)/(x-1)=b(y^n-1)/(y-1)$: II
, 1984 International audienceUsing the theory of linear forms in logarithms we generalize an earlier result with R.
Shorey, Tarlok Nath, Tarlok Nath Shorey
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Mock-Modular Forms of Weight One [PDF]
, 2013 In this thesis, we will study mock-modular forms of weight one and their Fourier coefficients. In particular, we will concentrate on the mock-modular forms whose shadows are dihedral newforms arising from ray class group characters of imaginary quadratic
Li, Yingkun
core
Resumming large collinear logarithms in the non-linear QCD evolution at high energy
, 2016 International audienceThe high-energy evolution in perturbative QCD suffers from a severe lack-of-convergence problem, due to higher order corrections enhanced by double and single transverse logarithms.
Edmond Iancu, Iancu, Edmond
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Explicit lower bounds for linear forms in two logarithms [PDF]
Journal de théorie des nombres de Bordeaux, 2008 We give an explicit lower bound for linear forms in two logarithms. For this we specialize the so-called Schneider method with multiplicity described in [10]. We substantially improve the numerical constants involved in existing statements for linear forms in two logarithms, obtained from Baker’s method or Schneider’s method with ...
openaire +1 more source
Powers of two as sums of two $k-$Fibonacci numbers [PDF]
, 2016 summary:Using the lower bound of linear forms in logarithms of Matveev and the theory of continued fractions by means of a variation of a result of Dujella and Pethő, we find all $k$-Fibonacci and $k$-Lucas numbers which are Fermat numbers.
Herrera, Jose L. +6 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source