Results 41 to 50 of about 5,342 (265)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Generalized Heptagonal Membership Function for Fully Fuzzy Linear Fractional Programming Problems

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences
    Identifying the optimum solution that satisfies the restrictions and maximizes or minimizes the objective function is the aim of fully fuzzy fractional programming (FFFLP). Due to the inclusion of both fuzzy parameters and fractional variables, this
Israa Hadi, Iden H. Al Kanani
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

A linear fractional bilevel programming problem with multichoice parameters

open access: yesCroatian Operational Research Review, 2017
A bilevel programming problem (BLPP) is a hierarchical optimization problem where the constraint region of the upper level is implicitly determined by the lower level optimization problem.
Ritu Arora, Kavita Gupta
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Efficient Fuzzy Solutions for Linear Fractional Programming Problems: Using Pentagonal Fuzzy Numbers and the Decomposition Method

open access: yesAcademic Science Journal
This paper presents an efficient method for solving fully fuzzy linear fractional programming (FFLFP) problems using pentagonal fuzzy numbers (PFNs) and the decomposition method.
Rebaz Mustafa, Maher Nawkhass
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

استخدام خوارزمية طريقة تطوير مو لد قطع المستوي لإيجاد الحل العددي لمسائل البرمجة الكسرية [PDF]

open access: yesEngineering and Technology Journal, 2008
There are many methods for solving Fractional Programming problems thatgetting the optimal solution of the problem where the values of variables arefractional numbers not integer numbers, But when there are conditions in theproblem that requires the ...
doaj   +1 more source

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