Results 61 to 70 of about 5,342 (265)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
FINANCIAL STRUCTURE OPTIMIZATION BY USING A GOAL PROGRAMMING APPROACH
Croatian Operational Research Review, 2012 This paper proposes a new methodology for solving the multiple objective fractional linear programming problems using Taylor’s formula and goal programming techniques.
Tunjo Perić, Zoran Babić
doaj
Some approaches to solving fuzzy linear fractional programming
Wasit Journal of Computer and Mathematics ScienceAn important planning tool is linear fuzzy fractional programming, it is used in various fields such as business, engineering, and others. We are trying to get one of the direct and effective methods that contain some arithmetic operations to obtain the
Waleed Mohammed Elaibi Elaibi +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Solving linear fractional multi-level programs
Operations Research and Decisions, 2012 OPERATIONS RESEARCH AND DECISIONS; ISSN 2081 ...
openaire +4 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
New insight on solving fuzzy linear fractional programming in material aspects
Fuzzy Optimization and Modeling, 2020 Recently, Srinivasan [On solving fuzzy linear fractional programming inmaterial aspects, Materials Today: Proceedings, https://doi.org/10.1016/j.matpr.2019.04.209] proposed a method to solve fractional linear programmingproblem under fuzzy environment ...
SAPAN DAS, Seyyed Ahamad Edalatpanah
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source