Results 81 to 90 of about 69,082 (292)

Cutting plane methods for general integer programming [PDF]

, 1993
Integer programming (IP) problems are difficult to solve due to the integer restrictions imposed on them. A technique for solving these problems is the cutting plane method.
Darby-Dowman, K, Hamid, FA, Mitra, G
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Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Fuzzy goal programming approach for solving linear fractional programming problems with fuzzy conditions [PDF]

Journal of Fuzzy Extension and Applications
Predicting the exact outcome of a real-life problem, which may occur in various fields like the industrial or healthcare sector, is challenging. Due to high information uncertainty and complicated factors influencing the industrial sector, traditional ...
Rajeev Prasad, Indrani Maiti, Sapan Das, Surapati Pramanik, Tarni Mandal   +4 more
doaj   +1 more source

A space-time pseudospectral discretization method for solving diffusion optimal control problems with two-sided fractional derivatives

, 2018
We propose a direct numerical method for the solution of an optimal control problem governed by a two-side space-fractional diffusion equation. The presented method contains two main steps.
Ali, Mushtaq Salh, Bozorgnia, Farid, Khosravian-Arab, Hassan, Shamsi, Mostafa, Torres, Delfim F. M.   +4 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Fractional programming for Stackelberg game under type-2 fuzzy environment [PDF]

Yugoslav Journal of Operations Research
This study intends to present a Stackelberg game model for design of the fractional type-2 fuzzy programming. In achieving this aspiration, we develop a probabilistic fuzzy multi-objective fractional linear programming where the entire parameters are of ...
Maiti Sumit Kumar, Roy Sankar Kumar, Saha Chinmay, Das Gora   +3 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A Novel Approach for Solving Quadratic Fractional Programming Problems

Croatian Operational Research Review, 2018
In this paper, quadratic fractional programming (QFP) problems involving a factorized or non-factorized objective function and subject to homogenous or non-homogenous constraints are considered.
Mustafa Sivri, Inci Albayrak, Gizem Temelcan   +2 more
doaj   +1 more source

An SDP Approach For Solving Quadratic Fractional Programming Problems [PDF]

, 2014
This paper considers a fractional programming problem (P) which minimizes a ratio of quadratic functions subject to a two-sided quadratic constraint. As is well-known, the fractional objective function can be replaced by a parametric family of quadratic ...
Nguyen, Van-Bong, Sheu, Ruey-Lin, Xia, Yong   +2 more
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