Results 51 to 60 of about 95,782 (269)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Wavelet discrete transform, ANFIS and linear regression for short-term time series prediction of air temperature

IJAIN (International Journal of Advances in Intelligent Informatics), 2017
This paper investigates the ability of Discrete Wavelet Transform and Adaptive Network-Based Fuzzy Inference System in time-series data modeling of weather parameters.
Devi Munandar
doaj   +1 more source

Simultaneous Inference for Time Series Functional Linear Regression

, 2022
We consider the problem of joint simultaneous confidence band (JSCB) construction for regression coefficient functions of time series scalar-on-function linear regression when the regression model is estimated by roughness penalization approach with flexible choices of orthonormal basis functions.
Cui, Yan, Zhou, Zhou
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Learning Heterogeneity in Causal Inference Using Sufficient Dimension Reduction

Journal of Causal Inference, 2019
Often the research interest in causal inference is on the regression causal effect, which is the mean difference in the potential outcomes conditional on the covariates. In this paper, we use sufficient dimension reduction to estimate a lower dimensional
Luo Wei, Wu Wenbo, Zhu Yeying
doaj   +1 more source

Comparative analysis of various modelling techniques for emission prediction of diesel engine fueled by diesel fuel with nanoparticle additives

European Mechanical Science, 2017
In this study, emissions of compression ignition engine fueled by diesel fuel with nanoparticleadditives was modeled by regression analysis, artificial neural network (ANN) and adaptiveneuro fuzzy inference system (ANFIS) methods.
Erdi Tosun, Tayfun Ozgur, Ceyla Ozgur, Mustafa Ozcanli, Hasan Serin, Kadir Aydin   +5 more
doaj   +1 more source

Improved Uncertainty Quantification for Neural Networks With Bayesian Last Layer

IEEE Access, 2023
Uncertainty quantification is an important task in machine learning - a task in which standard neural networks (NNs) have traditionally not excelled. This can be a limitation for safety-critical applications, where uncertainty-aware methods like Gaussian
Felix Fiedler, Sergio Lucia
doaj   +1 more source

Linear Regression and Its Inference on Noisy Network-Linked Data

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2022
AbstractLinear regression on network-linked observations has been an essential tool in modelling the relationship between response and covariates with additional network structures. Previous methods either lack inference tools or rely on restrictive assumptions on social effects and usually assume that networks are observed without errors.
Le, Can M., Li, Tianxi
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source