Results 51 to 60 of about 5,191,119 (260)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Comparative analysis of various modelling techniques for emission prediction of diesel engine fueled by diesel fuel with nanoparticle additives

European Mechanical Science, 2017
In this study, emissions of compression ignition engine fueled by diesel fuel with nanoparticleadditives was modeled by regression analysis, artificial neural network (ANN) and adaptiveneuro fuzzy inference system (ANFIS) methods.
Erdi Tosun, Tayfun Ozgur, Ceyla Ozgur, Mustafa Ozcanli, Hasan Serin, Kadir Aydin   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Developing a simple artificial intelligence fuzzy-based model for estimating saturated hydraulic conductivity of soil

Scientific Reports
Saturated hydraulic conductivity is one of the important physical properties of soil in modeling water and solute transport, irrigation management, and drainage issues. Laboratory and field methods for directly measuring this parameter are time-consuming
Mohammad Naderianfar
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Prediction versus inference: A dual-pipeline analytical framework for evaluating GAIN-based imputation in hypertension risk modeling

Informatics in Medicine Unlocked
Generative Adversarial Imputation Networks (GAIN) are increasingly used to address missing data and improve clinical prediction models, but whether GAIN-imputed data preserve reliable regression-based inference remains unclear.
Alan Chan, Gong Zhang, Weiwei Liao, Fei Liu, Yong-sheng Han, Tao Song, Jun Fu   +6 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Likelihood-based Imprecise Regression [PDF]

, 2011
We introduce a new approach to regression with imprecisely observed data, combining likelihood inference with ideas from imprecise probability theory, and thereby taking different kinds of uncertainty into account.
Marco E. G. V. Cattaneo, Cattaneo, Marco E.G.V., Wiencierz, Andrea, Cattaneo, Marco E. G. V., Andrea Wiencierz   +4 more
core   +1 more source

METHODS OF ESTIMATION IN MULTIPLE LINEAR REGRESSION: APPLICATION TO CLINICAL DATA MÉTODOS DE ESTIMACIÓN EN REGRESIÓN LINEAL MÚLTIPLE: APLICACIÓN A DATOS CLÍNICOS MÉTODOS DE ESTIMAÇÃO EM REGRESSÃO LINEAR MÚLTIPLA: APLICAÇÃO A DADOS CLÍNICOS

Revista Colombiana de Estadística, 2008
In this paper, we show different parameters estimation forms for multiple linear regression model. We used clinical data, where the interest was to verify the relationship among the mechanical assay maximum stress with femoral mass, femoral diameter and ...
Coelho-Barros Emílio Augusto, Simões Priscila Angelotti, Achcar Jorge Alberto, Martinez Edson Zangiacomi, Shimano Antônio Carlos   +4 more
doaj  

Foot Strike Angle Prediction and Pattern Classification Using LoadsolTM Wearable Sensors: A Comparison of Machine Learning Techniques

Sensors, 2020
The foot strike pattern performed during running is an important variable for runners, performance practitioners, and industry specialists. Versatile, wearable sensors may provide foot strike information while encouraging the collection of diverse ...
Stephanie R. Moore, Christina Kranzinger, Julian Fritz, Thomas Stӧggl, Josef Krӧll, Hermann Schwameder   +5 more
doaj   +1 more source