Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Rosendaal linear interpolation method appraising of time in therapeutic range in patients with 12-week follow-up interval after mechanical heart valve replacement. [PDF]
Front Cardiovasc Med, 2022 Zhu X +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Stable, simultaneous and proportional 4-DoF prosthetic hand control via synergy-inspired linear interpolation: a case series. [PDF]
J Neuroeng Rehabil, 2021 Lukyanenko P +5 more
europepmc +1 more source
Note on using the reciprocal function for a linear inverse interpolation [PDF]
, 1956 Hugh E. Stelson
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Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
A Linear Interpolation and Curvature-Controlled Gradient Optimization Strategy Based on Adam
AlgorithmsThe Adam algorithm is a widely used optimizer for neural network training due to efficient convergence speed. The algorithm is prone to unstable learning rate and performance degradation on some models. To solve these problems, in this paper, an improved
Haijing Sun +6 more
doaj +1 more source
Evaluation of the linear interpolation method in correcting the influence of slice thicknesses on radiomic feature values in solid pulmonary nodules: a prospective patient study. [PDF]
Ann Transl Med, 2021 Yang S, Wu N, Zhang L, Li M.
europepmc +1 more source
A table for linear and certain other interpolations on spectrograms [PDF]
, 1917 H. E. Merwin
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