Results 71 to 80 of about 113,300 (260)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

An Improved Medical Image Classification Algorithm Based on Adam Optimizer

Mathematics
Due to the complexity and illegibility of medical images, it brings inconvenience and difficulty to the diagnosis of medical personnel. To address these issues, an optimization algorithm called GSL(Gradient sine linear) based on Adam algorithm ...
Haijing Sun, Wen Zhou, Jiapeng Yang, Yichuan Shao, Lei Xing, Qian Zhao, Le Zhang   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Fuzzy rule interpolation for multidimensional input space with petroleum engineering application

, 2001
Fuzzy rule based systems have been very popular in many engineering applications. In petroleum engineering, fuzzy rules are normally constructed using some fuzzy rule extraction techniques to establish the petrophysical property prediction model. However,
Wong, K.W., Gedeon, T.D.
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Multi-Step PM2.5 Time Series Forecasting Approach for Mining Areas Using Last Day Observed, Correlation-Based Retrieval, and Interpolation

Computers
Monitoring PM2.5 in mining areas is essential for air quality management; however, most studies focus on single-step forecasts, limiting timely decision making.
Anibal Flores, Hugo Tito-Chura, Jose Guzman-Valdivia, Ruso Morales-Gonzales, Eduardo Flores-Quispe, Osmar Cuentas-Toledo   +5 more
doaj   +1 more source

Evaluation of rock burst tendency of coal seam based on Hamming distance method

Gong-kuang zidonghua, 2016
In allusion to shortcomings of current evaluation methods about rock burst tendency of coal seam, a model was built for comprehensively evaluating rock burst tendency of coal seam on basis of Hamming distance theory.
ZHANG Weiqiang, WANG Enyuan, LI Xuelong, KONG Xiangguo, LI Guoai   +4 more
doaj   +1 more source

Interpolation, outliers and inverse autocorrelations [PDF]

, 1990
The paper addresses the problem of estimating missing observations in linear, possibly nonstationary, stochastic processes when the model is known. The general case of any possible distribution of missing observations in the time series is considered ...
Maravall, Agustín, Peña, Daniel
core  

Linear Interpolation Lattice

, 1991
The Well-Known Analysis and Synthesis Filters of Linear Prediction Theory Are Extended Here to Include Linear Interpolation.
Stuller, John A., Coursey, Cameron K.
core   +1 more source