Results 81 to 90 of about 113,300 (260)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Methodology for the Differential Classification of Dengue and Chikungunya According to the PAHO 2022 Diagnostic Guide

Viruses
Arboviruses such as dengue, Zika, and chikungunya present similar symptoms in the early stages, which complicates their differential and timely diagnosis. In 2022, the PAHO published a guide to address this challenge. This study proposes a methodological
Wilson Arrubla-Hoyos, Jorge Gómez Gómez, Emiro De-La-Hoz-Franco   +2 more
doaj   +1 more source

Multi-Criteria Coverage Map Construction Based on Adaptive Triangulation-Induced Interpolation for Cellular Networks

IEEE Access, 2019
Wireless cellular communications lead to huge demands for estimating and visualizing the data about Quality of Service (QoS) for mobile network operators in the 5th Generation (5G) networks.
Yaxi Liu, Wei Huangfu, Haijun Zhang, Keping Long   +3 more
doaj   +1 more source

Estimates of the Aggregate Quarterly Capital Stock for the Post- War U.S. Economy [PDF]

We construct quarterly aggregate gross and net capital stock series for the post-war U.S. economy using annual capital stock, capital depreciation, and capital discard figures along with quarterly investment series. We construct nominal and real measures
Daniel Levy, Haiwei Chen
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Reading the Moody chart with a linear interpolation method. [PDF]

Sci Rep, 2022
Huang S.
europepmc   +1 more source

Fuzzy rule interpolation for multidimensional input spaces in determining d50c of hydrocyclones

, 2003
Fuzzy rule-based systems have been very popular in many engineering applications. In mineral engineering, fuzzy rules are normally constructed using some fuzzy rule extraction techniques to establish the determination model in predicting the d50c of ...
Wong, K.W., Eren, H., Fung, C.C., Gedeon, T.   +3 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Fast Path-Planning Algorithm for Mobile Robots via Straight Strategy

Applied Sciences
RRT*, which augments the RRT with the ChooseParent and Rewire steps, is a widely used algorithm for path planning. RRT*-based algorithms are effective for improving the quality of paths in the Rewire step.
Jihong Jeong, Jin-Woo Jung
doaj   +1 more source

Application of a linear interpolation algorithm in radiation therapy dosimetry for 3D dose point acquisition. [PDF]

Sci Rep, 2023
Guo Y, Li B, Li Y, Du W, Feng W, Feng S, Miao G.   +6 more
europepmc   +1 more source