Results 41 to 50 of about 4,312,384 (244)

Quick determination of Glyphosate and AMPA at sub µg/L in drinking water by direct injection into LC-MS/MS

Talanta Open, 2021
A sensitive, simple and quick method for the determination of glyphosate (Gly) and its degradation product, Aminomethyl phosphonic acid (AMPA), in water through ion chromatography coupled to quadrupole-linear ion trap mass spectrometry has been developed.
Vicent Yusà, Yovana Sanchís, Pablo Dualde, Elvira Carbonell, Clara Coscollà   +4 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Simulation Study of an Extremely Miniature Hyperbolic Linear Ion Trap

Zhipu Xuebao
The miniaturization of mass spectrometers has garnered significant attention in the analytical chemistry community. Leveraging the rapid advancements in micro-electro-mechanical system (MEMS), the development of chip-scale mass spectrometers has emerged ...
Yun-fan HE, Hong-liang ZHU, Zhuo-qing YANG, Yan WANG, Gui-fu DING, Jiu-wen SUN, Dong-ting WEI, Min LIU, Jin-yuan YAO   +8 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Linear RFQ Ion Trap for the Enriched Xenon Observatory [PDF]

, 2008
The design, construction, and performance of a linear radio-frequency ion trap (RFQ) intended for use in the Enriched Xenon Observatory (EXO) are described. EXO aims to detect the neutrinoless double-beta decay of {sup 136}Xe to {sup 136}Ba.
Flatt, B., LePort, F., O'Sullivan, K., Green, M., Wodin, J., Hallman, D., Baussan, E., Hargrove, C., Fierlinger, P., Montero Diez, M., Conley, R., Fairbank Jr., W., Farine, J., /Stanford U., Phys. Dept. /Neuchatel U. /SLAC /Colorado State U. /Laurentian U. /Carleton U. /Alabama U., DeVoe, R., Hall, K., Hodgson, J., Hauger, M., Neilson, R., Pocar, A., Breidenbach, M., Gratta, G.   +21 more
core  

Effects of collisional cooling on ion detection in a quadrupole ion trap mass spectrometer

, 2011
The effects of collisional cooling on the storage and detection of ions in a quadrupole ion trap mass spectrometer are examined. Four parameters that affect the storage of ions are evaluated: the pressure of the buffer gas: the qz value which establishes
Wu, H. F. ; 吳慧芬; Brodbelt, J. S.
core   +1 more source

Determination of Methotrexate in Serum by House-Made Quadrupole-Linear Ion Trap Mass Spectrometer

Zhipu Xuebao
Methotrexate (MTX) is a therapeutic drug that is widely used in clinic for treatment of a variety of cancers. However, MTX has limited selectivity and serious cytotoxicity, at the same time, there are problems such as narrow therapeutic window and large ...
Liang-ze LIU, Jie XIE, Zi-yu QU, Ke-ke YI, Di ZHANG, Ze-jian HUANG, Dan YAN, Xin-hua DAI, Xiang FANG, Zheng-yuan SHI, You JIANG, Xiao-ping YU   +11 more
doaj   +1 more source

Identification of Metabolites of 6′-Hydroxy-3,4,5,2′,4′-pentamethoxychalcone in Rats by a Combination of Ultra-High-Performance Liquid Chromatography with Linear Ion Trap-Orbitrap Mass Spectrometry Based on Multiple Data Processing Techniques

Molecules, 2016
In this study, an efficient strategy was established using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) to profile the in vivo metabolic fate of 6′-hydroxy-3,4,5,2′,4 ...
Siyi Liu, Yanyun Che, Fei Wang, Zhanpeng Shang, Jianqiu Lu, Shengyun Dai, Jiayu Zhang, Wei Cai   +7 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source