Results 101 to 110 of about 447,541 (315)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

LINEAR POSITIONING ERRORS OF 3 - AXIS MACHINE TOOL [PDF]

open access: yesApplied Computer Science, 2015
This paper presents results of 3-axis CNC machine tool diagnostics performed with XL-80 laser interferometer and XC-80 environmental compensation unit, including pressure, humidity and temperature sensors.
Jerzy JÓZWIK   +3 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Design of a five-axis ultra-precision micro-milling machine—UltraMill. Part 1: Holistic design approach, design considerations and specifications

open access: yes, 2009
High-accuracy three-dimensional miniature components and microstructures are increasingly in demand in the sector of electro-optics, automotive, biotechnology, aerospace and information-technology industries.
Wardle, F, Cheng, K, Huo, D
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Beam search heuristics for the single machine scheduling problem with linear earliness and quadratic tardiness costs [PDF]

open access: yes
In this paper, we consider the single machine scheduling problem with linear earliness and quadratic tardiness costs, and no machine idle time. We present heuristic algorithms based on the beam search technique.
Jorge M. S. Valente
core  

Linear generators for direct drive marine renewable energy converters [PDF]

open access: yes, 2003
This thesis is concerned with the development of linear generators for use as the power take off mechanism in marine renewable energy converters. Delivering significant power at the low velocities demanded by wave and tidal stream energy converters ...
Baker, Nicholas Jon
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Five-Axis Machine Tool Condition Monitoring Using dSPACE Real-Time System

open access: yes, 2012
This paper presents the design, development and SIMULINK implementation of the lumped parameter model of C-axis drive from GEISS five-axis CNC machine tool.
Longstaff, Andrew P.   +7 more
core   +1 more source

Weighted Linear Loss Projection Twin Support Vector Machine for Pattern Classification

open access: yesIEEE Access, 2019
Based on the recently proposed projection twin support vector machine (PTSVM) and least squares projection twin support vector machine (LSPTSVM), in this paper, we propose a weighted linear loss projection twin support vector machine, namely WLPTSVM for ...
Sugen Chen, Junfeng Cao, Zhong Huang
doaj   +1 more source

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