Results 81 to 90 of about 447,541 (315)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
IEEE AccessEnergy storage is a crucial technology for facilitating the integration of renewable energy sources (RES), such as wind and solar energy, into the electrical grid.
Morris Mugyema +3 more
doaj +1 more source
Synthesis of linear sequential machines
Information and Control, 1976 This paper studies the problem of synthesis of linear sequential machines from transition tables which are not necessarily coded and reduced. Two synthesis procedures are presented. One is adopted from linear system theory; the other is a modification of Cohn and Even's method. These two procedures not only are computationally simpler than any existing
openaire +2 more sources
Generalized Quadratic Linearization of Machine Models [PDF]
Journal of Control Science and Engineering, 2011 In the exact linearization of involutive nonlinear system models, the issue of singularity needs to be addressed in practical applications. The approximate linearization technique due to Krener, based on Taylor series expansion, apart from being applicable to noninvolutive systems, allows the singularity issue to be circumvented.
Parvathy Ayalur Krishnamoorthy +2 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2009 Using computer models to predict the dynamic performance of ultra-precision machine tools can help manufacturers to substantially reduce the lead time and cost of developing new machines. However, the use of electronic drives on such machines is becoming
Wardle, F, Cheng, K, Huo, D
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Linear consequent pole Halbach array flux reversal machine
The Journal of Engineering, 2019 This paper presents a linear variable reluctance permanent magnet (LVRPM) machine where the armature winding and inset Halbach array permanent magnets (PMs) are mounted on E-core stators.
Mohammad Abdul Hakim Raihan +3 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A Newton Method for Linear Programming
, 2002 A fast Newton method is proposed for solving linear programs with a very large ( 106) number of constraints and a moderate ( 102) number of variables. Such linear programs occur in data mining and machine learning.
O. L. Mangasarian, Mangasarian, Olvi
core
Towards Smoother Linear Locomotion Through Combined Linear Machine Structural Optimization Methods
EnergiesPermanent Magnet Linear Synchronous Motors (PMLSMs) are the dominant actuation solution for high-end manufacturing equipment, such as semiconductor lithography systems, owing to their superior force density and direct-drive capabilities.
Yiheng Chen, Zaixin Song, Yongtao Liang
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