Results 71 to 80 of about 1,682,433 (269)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Linear Feature-weighted Support Vector Machine
Fuzzy Information and Engineering, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Xing, Hong-Jie +3 more
openaire +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
IEEE AccessEnergy storage is a crucial technology for facilitating the integration of renewable energy sources (RES), such as wind and solar energy, into the electrical grid.
Morris Mugyema +3 more
doaj +1 more source
, 2020 This lecture gives an overview of the impacts on linear machine optics of machine imperfections due to incorrect field settings and misalignments. The effects of imperfections in dipole, quadrupole, and sextupole magnets are presented, along with beam ...
Wenninger, Jörg
core
A linear approach for sparse coding by a two-layer neural network
, 2015 Many approaches to transform classification problems from non-linear to linear by feature transformation have been recently presented in the literature. These notably include sparse coding methods and deep neural networks.
Montalto, Alessandro +2 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Linear consequent pole Halbach array flux reversal machine
The Journal of Engineering, 2019 This paper presents a linear variable reluctance permanent magnet (LVRPM) machine where the armature winding and inset Halbach array permanent magnets (PMs) are mounted on E-core stators.
Mohammad Abdul Hakim Raihan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source