Results 121 to 130 of about 3,497,223 (309)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Evaluation of the magnetization direction effects on ferrite PM brushless fractional machines [PDF]

, 2012
Permanent magnets are frequently adopted in small brushless machines for automotive applications. Normally anisotropic ferrites, but some research on bonded magnets is being carried on.
P. Ferraris, L. Ferraris, E. Poskovic, Ferraris, Paolo, Tenconi, Alberto, A. Tenconi, Ferraris, Luca, Poskovic, Emir   +7 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Paramètres clés pour la conception d’une machine pentaphasée à aimants à double polarité [PDF]

, 2014
Les systèmes de propulsion automobile ou navale nécessitent des entraînements électromécaniques compacts. Lorsque le diamètre alloué à la machine est faible, la mise en oeuvre d’une solution à grand nombre de pôles est difficile, ce qui interdit l ...
SCUILLER, Franck, ZAHR, Hussein, SEMAIL, Eric   +2 more
core  

Analytical Model and Feasibility Assessment of a Synchronous Reluctance Tubular Machine with an Additively Manufactured Mover

Energies
This paper presents the analytical model, feasibility assessment, and testing of a novel synchronous reluctance tubular machine, whose mover is manufactured using additive techniques. This approach enables the maximization of the machine’s saliency.
Giada Sala, Nicola Giannotta, Mattia Vogni, Claudio Bianchini, Fabio Immovilli   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

SVM-Maj: a majorization approach to linear support vector machines with different hinge errors [PDF]

Support vector machines (SVM) are becoming increasingly popular for the prediction of a binary dependent variable. SVMs perform very well with respect to competing techniques. Often, the solution of an SVM is obtained by switching to the dual.
Groenen, P.J.F., Bioch, J.C., Nalbantov, G.I.   +2 more
core  

Acknowledgement to Reviewers of Machines in 2014

, 2015
The editors of Machines would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...
Machines Editorial Office
core   +1 more source