Results 111 to 120 of about 3,497,223 (309)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Privacy-Preserving Linear and Nonlinear Approximation via Linear Programming [PDF]

, 2011
We propose a novel privacy-preserving random kernel approximation based on a data matrix A ? Rm n whose rows are divided into privately owned blocks.
Mangasarian, Olvi, Fung, Glenn
core  

Cogging force reduction in linear tubular flux switching permanent-magnet machines

Open Physics, 2018
The aim of this paper is to explore the possibility of using linear tubular flux switching permanent magnet machines in a free piston energy conversion (FPEC) system.
Lo Doudou Sarr, Amara Yacine, Barakat Georges, Chabour Ferhat   +3 more
doaj   +1 more source

Firing Rate Optimization of Deterministic Timed Event Graphs by Server Performance Improvement

IEEE Access, 2018
Timed event graphs are a subclass of Petri nets that are commonly applied for modeling and controlling manufacturing systems. In this paper, we investigate the problem of improving the performance of machines (servers) in timed event graphs in order to ...
Zhou He, Miao Liu, Ning Ran, Zhiwu Li
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Vending Machines

, 2018
Full Line Vending Machines Total Refreshment Solutions Ada & Credit Card Ready Soda, Water, Snacks, Coffee, Ice Cream, Cold Food, Combo Vendors Healthy Vending 100% Financing.
Avanti Vending Machines (6101549)
core   +1 more source

Support Vector Machines in R [PDF]

, 2005
Being among the most popular and efficient classification and regression methods currently available, implementations of support vector machines exist in almost every popular programming language.
Kurt Hornik, David Meyer, Karatzoglou, Alexandros, Hornik, Kurt, Meyer, David, Alexandros Karatzoglou   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Scheduling Jobs on Unreliable Machines Subject to Linear Risk

Logistics
Background: This paper addresses a new class of scheduling problems in the context of machines subject to (unrecoverable) interruptions; i.e., when a machine fails, the current and subsequently scheduled work on that machine is lost.
Alessandro Agnetis, Ilaria Salvadori
doaj   +1 more source

Magnetically Nonlinear Dynamic Models of Synchronous Machines and Experimental Methods for Determining Their Parameters

Energies, 2019
This paper deals with rotary and linear synchronous reluctance machines and synchronous permanent magnet machines. It proposes a general method appropriate for determining the two-axis dynamic models of these machines, where the effects of slotting ...
Gorazd Štumberger, Bojan Štumberger, Tine Marčič   +2 more
doaj   +1 more source