Results 91 to 100 of about 3,497,223 (309)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Linear tubular switched reluctance motor for heart assistance circulatory: Analytical and finite element modeling [PDF]

, 2011
A linear tubular switched reluctance motor is presented. This actuator is devoted to be used as a left ventricular assist device (LVAD). In order to avoid thrombosis, this actuator includes pump and valve functions. By using a St. Jude Medical mechanical
Leprince, Pascal, Martinez, Nicolas, N. Martinez, Llibre, Jean-François, B. Nogarede, P. Leprince, J-F. Llibre, Leprince, P., Nogarède, Bertrand, Martinez, N.   +9 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

A Newton Method for Linear Programming [PDF]

, 2002
A fast Newton method is proposed for solving linear programs with a very large ( 106) number of constraints and a moderate ( 102) number of variables. Such linear programs occur in data mining and machine learning.
O. L. Mangasarian, Mangasarian, Olvi
core  

Analytical and circuital modeling of commutation transients in phase-split synchronous motors supplied by multiple load commutated inverters

, 2008
Phase-split synchronous motors supplied by multiple three-phase Load Commutated Inverters are of importance in high power applications. A criticality of such systems is the possibility that commutations within different stator windings may overlap ...
Simone Castellan, TESSAROLO, ALBERTO, CASTELLAN, Simone, Alberto Tessarolo   +3 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

RSVM: Reduced Support Vector Machines [PDF]

, 2001
An algorithm is proposed which generates a nonlinear kernel-based separating surface that requires as little as 1% of a large dataset for its explicit evaluation.
Olvi L. Mangasarian, Mangasarian, Olvi, Yuh-Jye Lee, Lee, Yuh-Jye   +3 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Robust Linear and Support Vector Regression [PDF]

, 2000
The robust Huber M-estimator, a differentiable cost function that is quadratic for small errors and linear otherwise, is modeled exactly, in the original primal space of the problem, by an easily solvable simple convex quadratic program for both linear ...
Mangasarian, Olvi, Musicant, David
core