Results 81 to 90 of about 88,337 (264)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Cogging force reduction in linear tubular flux switching permanent-magnet machines
Open Physics, 2018 The aim of this paper is to explore the possibility of using linear tubular flux switching permanent magnet machines in a free piston energy conversion (FPEC) system.
Lo Doudou Sarr +3 more
doaj +1 more source
Firing Rate Optimization of Deterministic Timed Event Graphs by Server Performance Improvement
IEEE Access, 2018 Timed event graphs are a subclass of Petri nets that are commonly applied for modeling and controlling manufacturing systems. In this paper, we investigate the problem of improving the performance of machines (servers) in timed event graphs in order to ...
Zhou He, Miao Liu, Ning Ran, Zhiwu Li
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Scheduling Jobs on Unreliable Machines Subject to Linear Risk
LogisticsBackground: This paper addresses a new class of scheduling problems in the context of machines subject to (unrecoverable) interruptions; i.e., when a machine fails, the current and subsequently scheduled work on that machine is lost.
Alessandro Agnetis, Ilaria Salvadori
doaj +1 more source
Energies, 2019 This paper deals with rotary and linear synchronous reluctance machines and synchronous permanent magnet machines. It proposes a general method appropriate for determining the two-axis dynamic models of these machines, where the effects of slotting ...
Gorazd Štumberger +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source