Results 131 to 140 of about 604,873 (258)

Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models. [PDF]

PLoS Comput Biol, 2023
Hake A, Germann A, de Beer C, Thielen A, Däumer M, Preiser W, von Briesen H, Pfeifer N.   +7 more
europepmc   +1 more source

Relationship Between COPD Progression and Frailty Progression: A Five-year Observation in Real Clinical Practice

International Journal of COPD
Koichi Nishimura,1,2 Masaaki Kusunose,3 Ayumi Shibayama,4 Kazuhito Nakayasu5 1National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; 2Clinic Nishimura, Ayabe, Kyoto, Japan; 3Department of Respiratory Medicine, National Center for Geriatrics ...
Nishimura K, Kusunose M, Shibayama A, Nakayasu K   +3 more
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Non-Linear Mixed Models for the Characterization of Growth Trajectory Measured by Ultrasound of 'San Pedreño' Creole Pig Breed From Colombia. [PDF]

Vet Med Sci
Salamanca-Carreño A, Parés-Casanova PM, Rangel-Pachón DE, Valverde A, Toalombo-Vargas PA, Vélez-Terranova M.   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A tutorial on conducting sample size and power calculations for detecting treatment effect heterogeneity in cluster randomized trials with linear mixed models. [PDF]

Int J Epidemiol
Ryan Baumann M, Taljaard M, Heagerty PJ, Harhay MO, Tong G, Wang R, Li F.   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

plmmr: an R package to fit penalized linear mixed models for genome-wide association data with complex correlation structure. [PDF]

Brief Bioinform
Peter TK, Reisetter AC, Lu Y, Rysavy OA, Breheny PJ.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

When the outcome is compositional: A method for conducting compositional response linear mixed models for physical activity, sedentary behaviour and sleep research. [PDF]

PLoS One
Miatke A, Stanford T, Olds T, Fraysse F, Maher C, Martin-Fernandez JA, Dumuid D.   +6 more
europepmc   +1 more source