Results 151 to 160 of about 604,873 (258)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Power and sample size for reversible linear mixed models with clustering and longitudinality: GLIMMPSE Version 3. [PDF]

PLoS One
Glueck DH, Li Q, Macleod AJ, Litkowski EM, Yang X, Bian J, Ritzhaupt AD, Sommer M, Valle N, Shaw JR, Muller KE.   +10 more
europepmc   +1 more source

BGWAS: Bayesian variable selection in linear mixed models with nonlocal priors for genome-wide association studies. [PDF]

BMC Bioinformatics, 2023
Williams J, Xu S, Ferreira MAR.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Comparing Wastewater-Based and Case-Based <i>R_t</i> Estimates of SARS-CoV-2 Transmission in Georgia Using Generalized Linear Mixed Models. [PDF]

Epidemiol Infect
Edmunds S, Ajelli M, Litvinova M, Landsittel D.   +3 more
europepmc   +1 more source

Streamlined Variational Inference for Linear Mixed Models with Crossed Random Effects. [PDF]

J Comput Graph Stat, 2023
Menictas M, Di Credico G, Wand MP.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The role of social determinants of health in post-diagnosis gestational weight gain trajectories among women with gestational diabetes mellitus: a multicenter cohort using latent class linear mixed models. [PDF]

BMC Public Health
Luo D, Liu X, Hu K, Ji L, Xie W, Kang L, He Q, Mei J, He J.   +8 more
europepmc   +1 more source

REHE: Fast variance components estimation for linear mixed models. [PDF]

Genet Epidemiol, 2021
Yue K, Ma J, Thornton T, Shojaie A.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source