Results 81 to 90 of about 5,219,358 (316)

Partially linear models on Riemannian manifolds [PDF]

open access: yes, 2010
In partially linear models the dependence of the response y on (x^T,t) is modeled through the relationship y=\x^T \beta+g(t)+\epsilon where \epsilon is independent of (x^T,t).
Gonzalez-Manteiga, Wenceslao   +2 more
core  

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Creation of a panel of genetic markers for breeding of a large white breed pigs on the reproductive fitness

open access: yesАграрная наука Евро-Северо-Востока, 2017
The article presents studies of the effect of SNP of genes PRLR, LEP, ESR, FSHb, MC4R, LIF, POU1F1, GH on the reproductive performance of large white pigs. The analysis was carried out using linear models of mixed type.
A. Yu. Kolosov   +2 more
doaj  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Linear Stochastic Models of Nonlinear Dynamical Systems

open access: yes, 1998
We investigate in this work the validity of linear stochastic models for nonlinear dynamical systems. We exploit as our basic tool a previously proposed Rayleigh-Ritz approximation for the effective action of nonlinear dynamical systems started from ...
B. A. Finlayson   +17 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Least-Squares Means: The R Package lsmeans

open access: yesJournal of Statistical Software, 2016
Least-squares means are predictions from a linear model, or averages thereof. They are useful in the analysis of experimental data for summarizing the effects of factors, and for testing linear contrasts among predictions. The lsmeans package (Lenth 2016)
Russell V. Lenth
doaj   +1 more source

Conservative accounting and linear information valuation models [PDF]

open access: yes, 2004
Prior research using the residual income valuation model and linear information models has generally found that estimates of firm value are negatively biased.
Choi, Y S, O'Hanlon, J F, Pope, P F
core  

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