Results 41 to 50 of about 590,268 (302)

Optimizing Linear Models via Sinusoidal Transformation for Boosted Machine Learning in Medicine

مجلة كلية الطب, 2020
Background: Machine learning relies on a hybrid of analytics, including regression analyses. There have been no attempts to deploy a sinusoidal transformation of data to enhance linear regression models.
Ahmed Al-Imam
doaj  

Research on linear regression algorithm [PDF]

MATEC Web of Conferences
Linear regression is one of the most widely used predictive models in statistics and machine learning. This paper aims to comprehensively discuss the theoretical basis, mathematical principle and application of linear regression algorithm in various ...
Qu Kecheng
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

UNA GENERALIZACIÓN DE LA ESTADÍSTICA DE COOK UNA GENERALIZACIÓN DE LA ESTADÍSTICA DE COOK

Revista Colombiana de Estadística, 2001
This paper presents a generalization of the Cook's statistics useful in the identification of influential observations in the least squares estimation of the multiple regression parameters.En este artículo se presenta una generalización de la estadística
Jiménez M. José
doaj  

A High Dimensional Omnibus Regression Test

Stats
Consider regression models where the response variable Y only depends on the p×1 vector of predictors x=(x1,…,xp)T through the sufficient predictor SP=α+xTβ. Let the covariance vector Cov(x,Y)=ΣxY.
Ahlam M. Abid, Paul A. Quaye, David J. Olive   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Do you know your r2?

ADMET and DMPK, 2020
The prediction of solubility of drugs usually calls on the use of several open-source/commercially-available computer programs in the various calculation steps.
Alex Avdeef
doaj   +1 more source

Error bounds for the convex loss Lasso in linear models [PDF]

, 2017
In this paper we investigate error bounds for convex loss functions for the Lasso in linear models, by first establishing a gap in the theory with respect to the existing error bounds.
Deléamont, Pierre-Yves, Pierre-Yves Deléamont, Hannay, Mark, Mark Hannay   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Basics of Statistics for Clinical Research in Hand Surgery

Revista Iberoamericana de Cirugía de la Mano, 2018
Statistics, the science of numerical evaluation, helps in determining the real value of a hand surgical intervention. Clinical research in hand surgery cannot improve without considering the application of the most appropriate statistical procedures. The
Roberto S. Rosales, Isam Atroshi
doaj   +1 more source