Results 61 to 70 of about 11,029,261 (299)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Location–scale models in ecology and evolution: Heteroscedasticity in continuous, count and proportion data

Methods in Ecology and Evolution
Biological data often violate the assumption of constant variance, yet such heteroscedasticity can reflect meaningful biological processes such as plasticity, canalization or stress responses. Despite this, most models treat variance as statistical noise.
Shinichi Nakagawa, Santiago Ortega, Elena Gazzea, Malgorzata Lagisz, Anna Lenz, Erick Lundgren, Ayumi Mizuno   +6 more
doaj   +1 more source

On Some Test Statistics for Coefficients in the Ridge, Liu and Kibria–Lukman Linear Regression Models: A Simulation Study

Data Science in Science
Ridge, Liu, and Kibria–Lukman regression methods that have been proposed to solve the multicollinearity problem for both linear and generalized linear regression models (Kibria and Lukman, Shewa and Ugwuowo). This paper considers several different ridge,
Sergio Perez Melo, Sultana Mubarika Rahman Chowhdury, Zoran Bursac, B. M. Golam Kibria   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Book Review for

, 2007
xt has achieved its goal of presenting concepts in an understandable way to an audience familiar with the basic theory of linear algebra. The central theme of the text seems to focus on building models.
Linear Models
core  

Model‐based ordination for phenological studies: From controlling sampling bias to inferring temporal associations

Methods in Ecology and Evolution
Willig et al. (Methods in Ecology and Evolution, 15, 868–885, 2024) cautioned that unequal sampling effort and pseudoreplication can bias the characterisation of species phenology using circular statistics.
Hao Ran Lai
doaj   +1 more source

THE BIVARIATE CORRELATION COEFFICIENT: FROM CONCEPT TO APPLICATION

Central Asian Journal of Medical Hypotheses and Ethics
The bivariate correlation coefficient is among the most fundamental and widely applied measures in statistical analysis, offering a quantitative assessment of the association between two continuous variables.
Farrokh Habibzadeh
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Forecasting telecommunications data with linear models [PDF]

For telecommunication companies to successfully manage their business, companies rely on mapping future trends and usage patterns. However, the evolution of telecommunications technology and systems in the provision of services renders imperfections in ...
Tan, Joachim, Madden, Gary G
core  

Insensitivity Regions and Outliers in Mixed Models with Constraints

Austrian Journal of Statistics, 2016
A procedure for detecting outliers in regular linear regression models with constraints on mean value parameters is presented. A problem, how unknown variance components influence the optimum quality of used test statistics, is studied by sensitivity ...
Eva Fišerová, Lubomír Kubáček
doaj   +1 more source