Results 51 to 60 of about 538,044 (257)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Model‐based ordination for phenological studies: From controlling sampling bias to inferring temporal associations

Methods in Ecology and Evolution
Willig et al. (Methods in Ecology and Evolution, 15, 868–885, 2024) cautioned that unequal sampling effort and pseudoreplication can bias the characterisation of species phenology using circular statistics.
Hao Ran Lai
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

THE BIVARIATE CORRELATION COEFFICIENT: FROM CONCEPT TO APPLICATION

Central Asian Journal of Medical Hypotheses and Ethics
The bivariate correlation coefficient is among the most fundamental and widely applied measures in statistical analysis, offering a quantitative assessment of the association between two continuous variables.
Farrokh Habibzadeh
doaj   +1 more source

Min-Max, Min-Max-Median, and Min-Max-IQR in Deciding Optimal Diagnostic Thresholds: Performances of a Logistic Regression Approach on Simulated and Real Data

Applied Medical Informatics, 2023
Combining biomarkers and their statistics is used to increase the prediction performance of a diagnosis, but no gold standard method exists. We introduced and evaluated an approach using linear combinations of summary-based statistics tested in logistic ...
Ilie-Andrei CONDURACHE, Sorana D. BOLBOACĂ   +1 more
doaj  

Insensitivity Regions and Outliers in Mixed Models with Constraints

Austrian Journal of Statistics, 2016
A procedure for detecting outliers in regular linear regression models with constraints on mean value parameters is presented. A problem, how unknown variance components influence the optimum quality of used test statistics, is studied by sensitivity ...
Eva Fišerová, Lubomír Kubáček
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Measuring statistical anxiety and attitudes toward statistics: The development of a comprehensive Danish instrument (HFS-R)

Cogent Education, 2018
Motivated by experience with students’ psychological barriers to learning statistics, we modified and extended the Statistical Anxiety Rating Scale (STARS) to develop a contemporary and valid (face, content, criterion and construct) Danish measure of ...
Tine Nielsen, Svend Kreiner
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Estimating Traffic Accidents in Turkey Using Differential Evolution Algorithm

Selected Scientific Papers: Journal of Civil Engineering, 2017
Estimating traffic accidents play a vital role to apply road safety procedures. This study proposes Differential Evolution Algorithm (DEA) models to estimate the number of accidents in Turkey.
Akgüngör Ali Payıdar, Korkmaz Ersin
doaj   +1 more source