Results 21 to 30 of about 266,949 (180)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Generalizations of entanglement based on coherent states and convex sets

, 2002
Unentangled pure states on a bipartite system are exactly the coherent states with respect to the group of local transformations. What aspects of the study of entanglement are applicable to generalized coherent states?
A. Aspect, A. Lerda, A. Osterloh, A. Wilce, B. Yurke, B. Yurke, B.M. Terhal, C. Bennett, C.D. Batista, C.D. Batista, C.H. Bennett, C.H. Bennett, C.H. Bennett, C.H. Bennett, E. Schrödinger, E. Schrödinger, E. Schrödinger, E.G. Beltrametti, Emanuel Knill, G. Vidal, Gerardo Ortiz, H. Buhrman, H. Ollivier, Howard Barnum, I. Namioka, J. Schliemann, J. Schliemann, J.F. Clauser, J.S. Bell, K. Eckert, K. Grobe, Lorenza Viola, M. Lewenstein, M.A. Rowe, M.B. Plenio, M.J. Donald, M.Y. Ivanov, P. Jordan, P. Zanardi, P. Zanardi, P. Zanardi, R. Delbourgo, R. Delbourgo, R. Gilmore, R. Somma, R.F. Werner, S. Gudder, T.J. Osborne, W. Dür, W.-M. Zhang   +49 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Spectra of linear fractional composition operators and properties of universal operators [PDF]

, 2017
The topics of this thesis in mathematics belong to the area of operator theory which, in general, studies linear transformations between complete normed vector spaces.
Schroderus, Riikka
core  

The $\ell^s$-boundedness of a family of integral operators on UMD Banach function spaces

, 2018
We prove the $\ell^s$-boundedness of a family of integral operators with an operator-valued kernel on UMD Banach function spaces. This generalizes and simplifies earlier work by Gallarati, Veraar and the author, where the $\ell^s$-boundedness of this ...
A Amenta, AP Calderón, C Gallarati, C Gallarati, C Gallarati, C. Bennett, D Cruz-Uribe, GP Curbera, H Amann, J Bourgain, J García-Cuerva, J Prüss, J Prüss, JL Rubio de Francia, JMAM Neerven van, JMAM Neerven van, K Moen, L Weis, Loukas Grafakos, M Köhne, M Meyries, Nick Lindemulder, P Clément, Philippe Clément, S Kwapień, TS Hänninen, Tuomas Hytönen, Tuomas Hytönen   +27 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Toeplitz operators defined by sesquilinear forms: Fock space case

, 2014
The classical theory of Toeplitz operators in spaces of analytic functions deals usually with symbols that are bounded measurable functions on the domain in question.
Rozenblum, Grigori, Vasilevski, Nikolai
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source