FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
A non-linear optimization based robust attribute weighting model for the two-class classification problems. [PDF]
PeerJ Comput Sci, 2023 Alhudhaif A.
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Computational issues and related mathematics of an exponential annealing homotropy for conic optimization [PDF]
, 2007 Thesis (S.M.)--Massachusetts Institute of Technology, Computation for Design and Optimization Program, 2007.Includes bibliographical references (p. 105-106).We present a further study and analysis of an exponential annealing based algorithm for convex ...
Chen, Jeremy, S.M. Massachusetts Institute of Technology
core
GKLOMLI: a link prediction model for inferring miRNA-lncRNA interactions by using Gaussian kernel-based method on network profile and linear optimization algorithm. [PDF]
BMC Bioinformatics, 2023 Wong L +5 more
europepmc +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
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Constrained Optimization Involving Expensive Function Evaluations: A Sequential Approach [PDF]
This paper presents a new sequential method for constrained non-linear optimization problems.The principal characteristics of these problems are very time consuming function evaluations and the absence of derivative information.
Brekelmans, R.C.M. +3 more
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Road network optimization using heuristic and linear programming
Journal of Forest Science, 2010 To minimize the cost of logging, it is necessary to optimize the road density. The aim of this study was to determine optimal road spacing (ORS) in Northern Austria. The stepwise regression method was used in modelling.
M. R. Ghaffariyan +5 more
doaj +1 more source
A Local Planner for Accurate Positioning for a Multiple Steer-and-Drive Unit Vehicle Using Non-Linear Optimization. [PDF]
Sensors (Basel), 2022 Andreasson H, Larsson J, Lowry S.
europepmc +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source