Results 81 to 90 of about 390,488 (265)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

GKLOMLI: a link prediction model for inferring miRNA-lncRNA interactions by using Gaussian kernel-based method on network profile and linear optimization algorithm. [PDF]

BMC Bioinformatics, 2023
Wong L, Wang L, You ZH, Yuan CA, Huang YA, Cao MY.   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Road network optimization using heuristic and linear programming

Journal of Forest Science, 2010
To minimize the cost of logging, it is necessary to optimize the road density. The aim of this study was to determine optimal road spacing (ORS) in Northern Austria. The stepwise regression method was used in modelling.
M. R. Ghaffariyan, K. Stampfer, J. sessions, T. Durston, M. Kuehmaier, Ch. Kanzian   +5 more
doaj   +1 more source

A Local Planner for Accurate Positioning for a Multiple Steer-and-Drive Unit Vehicle Using Non-Linear Optimization. [PDF]

Sensors (Basel), 2022
Andreasson H, Larsson J, Lowry S.
europepmc   +1 more source

Linearized Optimal Transport on Manifolds

SIAM Journal on Mathematical Analysis
45 pages, 10 figures Numerical examples can be generated using the code at https://gitlab.gwdg.de/bernhard.schmitzer ...
Clément Sarrazin, Bernhard Schmitzer
openaire   +4 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Efficient Hardware Accelerator Design of Non-Linear Optimization Correlative Scan Matching Algorithm in 2D LiDAR SLAM for Mobile Robots. [PDF]

Sensors (Basel), 2022
Hu A, Yu G, Wang Q, Han D, Zhao S, Liu B, Yu Y, Li Y, Wang C, Zou X.   +9 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

COMTOP: Protein Residue-Residue Contact Prediction through Mixed Integer Linear Optimization. [PDF]

Membranes (Basel), 2021
Reza MS, Zhang H, Hossain MT, Jin L, Feng S, Wei Y.   +5 more
europepmc   +1 more source