Results 91 to 100 of about 390,488 (265)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A hyper-matheuristic approach for solving mixed integer linear optimization models in the context of data envelopment analysis. [PDF]

PeerJ Comput Sci, 2022
Gonzalez M, López-Espín JJ, Aparicio J, Talbi EG.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Optimal Policies for Conjunctive-Use and Cropping Pattern for Al-Wand Basin

مجلة النهرين للعلوم الهندسية, 2017
Applying conjunctive use between surface water and ground water is getting widely used at many regions in the world, due to the increasing need of water resources, especially when large quantities of water and for long time are used for irrigation ...
Amer Hassan Al-Haddad, Zainab Kadhim Jabal   +1 more
doaj  

KAFA-Merge: Model Merging Method With Layer-Based Bayes+Linear Search

IEEE Access
In this paper, we consider the model merging process for large language models (LLMs) under a two-stage optimization framework. Traditional merging methods usually apply fixed blending rates to all layers, which ignores the different levels of ...
Muzaffer Kaan Yuce, Mehmet Fatih Amasyali   +1 more
doaj   +1 more source

OPTIMIZATION OF LINEAR HYBRID CONTROL SYSTEMS

Наука и техника, 2007
A linear optimal control problem for a hybrid system is solved. The Cauchy formula is derived with its help the initial problem is reduced to a special linear programming.
O. R. Gabasova
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Numerical modelling and optimization of vacuum field during plasma initiation in view of the operation of the COMPASS Upgrade tokamak

Nuclear Fusion
The COMPASS Upgrade tokamak (Vondracek et al 2021 Fusion Eng. Des. 169 112490) will have dimensions $R_0 = 0.894\ \mathrm{m}$ and $a{\sim}0.27\ \mathrm{m}$ with high-field ( $B_t{\sim}5\ \mathrm{T}$ ), high-current ( $I_p{\sim}2\ \mathrm{MA}$ ), high ...
F. Jaulmes, O. Bardsley, J. Krbec, H.-T. Kim, J. Hromadka, J. Havliček, A. Havranek, J. Hečko, M. Imrišek, S. Marchioni, L. Kripner, O. Ficker, the COMPASS Upgrade Team   +12 more
doaj   +1 more source

Designing Nutritionally Adequate and Climate-Friendly Diets for Omnivorous, Pescatarian, Vegetarian and Vegan Adolescents in Sweden Using Linear Optimization. [PDF]

Nutrients, 2021
Eustachio Colombo P, Elinder LS, Lindroos AK, Parlesak A.   +3 more
europepmc   +1 more source

Linear optimization queries [PDF]

Proceedings of the eighth annual symposium on Computational geometry - SCG '92, 1992
Jirí Matousek 0001, Otfried Schwarzkopf
openaire   +1 more source