Results 91 to 100 of about 5,277,522 (305)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
An exact method for a discrete multiobjective linear fractional optimization [PDF]
Integer linear fractional programming problem with multiple objective MOILFP is an important field of research and has not received as much attention as did multiple objective linear fractional programming.
Chergui, M. E-A, Moulai, M.
core
Suboptimal solutions to network team optimization problems [PDF]
, 2009 Smoothness of the solutions to network team optimization problems with statistical information structure is investigated. Suboptimal solutions expressed as linear combinations of elements from sets of basis functions containing adjustable parameters are ...
Gnecco, Giorgio, Sanguineti, Marcello
core
Optimization Library for Interactive Multi-Criteria Optimization Tasks [PDF]
, 2012 The commercial library Optimization 2.1 for interactive multi-criteria optimization tasks has been released along with Dymola 2013. The library offers several numerical optimization algorithms for solving different kinds of optimization tasks.
Pfeiffer, Andreas, Andreas Pfeiffer
core +1 more source
Counterfactual explanations for linear optimization
European Journal of Operational ResearchThe concept of counterfactual explanations (CE) has emerged as one of the important concepts to understand the inner workings of complex AI systems. In this paper, we translate the idea of CEs to linear optimization and propose, motivate, and analyze three different types of CEs: strong, weak, and relative. While deriving strong and weak CEs appears to
Jannis Kurtz +2 more
openaire +3 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
On Optimal Testing of Linearity
Linearity testing has been a focal problem in property testing of functions. We combine different known techniques and observations about linearity testing in order to resolve two recent versions of this task. First, we focus on the online manipulations model introduced by Kalemaj, Raskhodnikova and Varma (ITCS 2022 \& Theory of Computing 2023 ...
Vipul Arora 0002, Esty Kelman, Uri Meir
openaire +3 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source