Results 61 to 70 of about 383,425 (312)
The catalyst-free polytransesterification for obtaining linear PGS optimized with use of 22 factorial design [PDF]
, 2023 Michał Wrzecionek +4 more
openalex +1 more source
Neighborhood Persistency of the Linear Optimization Relaxation of Integer Linear Optimization
Mathematical Programming, 2022 Abstract For an integer linear optimization (ILO) problem, persistency of its linear optimization (LO) relaxation is a property that for every optimal solution of the relaxation that assigns integer values to some variables, there exists an optimal solution of the ILO problem in which these variables retain the ...
Kei Kimura, Kotaro Nakayama
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Energies, 2019 Chile has abundant solar and wind resources and renewable generation is becoming competitive with fossil fuel generation. However, due to renewable resource variability their large-scale integration into the electricity grid is not trivial.
Serguey A. Maximov +2 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Optimal Predictive Linear Discriminants
The Annals of Statistics, 1974 When classifying an observation $\mathbf{z}$ which has arisen (with known prior probabilities) from one of two $p$-variate nonsingular normal populations with known parameters, the discriminant, say $U$, which minimizes the total probability of misclassification is based on the logarithm of the ratio of the densities of the two populations.
Enis, Peter, Geisser, Seymour
openaire +3 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
KEY COMPETENCE AS A BASIS FOR INNOVATION PROJECTS MANAGEMENT
Сучасний стан наукових досліджень та технологій в промисловості, 2019 By the implementing an enterprise development program, the existing key competence of the organization may undergo significant changes. Also introducing innovations, you can get not only benefits, but additional problems and even risks.
Lyudmyla Chernova
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source