Results 31 to 40 of about 685 (153)

AI‐Assisted Fungal Detection in Dermatopathology: A Study on Accuracy, Efficiency, and Usability

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives AI‐based image analysis is increasingly applied in pathology. Excluding fungal elements in PAS‐stained skin sections is labor‐intensive and well suited for AI assistance. While fungal detection in nails has been studied, skin‐biopsy applications and real‐world benefit remain limited.
Paul Schmidle, Tobias Lang, Sebastian Springenberg, Diego Calvopiña, Theresa Köhler, Valentina Getova, Ana‐Maria Gebing, Sonja Hetzer, Johanna Pierrone, Valentin Aebischer, Dieter Metze, Almut Böer‐Auer, Stephan Alexander Braun   +12 more
wiley   +1 more source

A Case of Refractory Giant Porokeratosis, Treated With a New Treatment Approach Consisting of Ablative CO2 Laser and Methotrexate

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Combined fractional CO2 laser + MTX may be an option for refractory GPK, with vigilant biopsy confirmation and malignancy surveillance.
Ali Asilian, Mohammad Shoushtarizadeh, Sarah Seyedyousefi, Mohamad Beheshti, Malih Aminjavaheri   +4 more
wiley   +1 more source

Squamous Cell Carcinoma Arising from Linear Porokeratosis - a case report and review of the literature

, 2017
Porokeratosis belongs to a group of disorders of keratinization that are characterized by the histopathological feature of the cornoid lamella, a column of tightly fitted parakeratotic cells. The etiology of porokeratosis is still unclear.
Milena Milovanović, Ivana Tufegdžić, Milica Rajović, Kristina Kostić, Lidija Kandolf Sekulović, Snežana Radoš   +5 more
core   +1 more source

Rare Variant of Porokeratosis: A Case Report

, 2021
There are 5 clinically distinct variants of porokeratosis, including classic porokeratosis of Mibelli, disseminated superficial (actinic) porokeratosis, linear porokeratosis, punctate porokeratosis, and porokeratosis palmaris et plantaris disseminate ...
Awad, Nardin
core  

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

, 2023
Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella.
Cristian Navarrete-Dechent, Paweł Pietkiewicz, Natalia Salwowska, Ihor Kohut, Anna Pogorzelska-Antkowiak, Monika Bowszyc-Dmochowska, Katarzyna Korecka, Adarsha Adhikari   +7 more
core   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

A Multifaceted Holistic Review of the Literature on Scar Dermatoses

International Wound Journal, Volume 23, Issue 5, May 2026.
ABSTRACT Many cutaneous diseases originate or manifest in scars. Scars are areas of compromised skin, which renders them a vulnerable cutaneous district for diseases to develop. The pathophysiology explaining why some dermatoses grow in scars is not yet thoroughly explored. The present study reviews the present literature on scar dermatoses.
Dana Maria Khoury, Elias El Tayar, Edward Eid, Firas F. Haddad, Ossama Abbas, Mazen Kurban   +5 more
wiley   +1 more source

Successful Treatment of Refractory Disseminated Superficial Actinic Porokeratosis With Topical Ruxolitinib

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT This is the first documented case of disseminated superficial actinic porokeratosis (DSAP) successfully treated with topical ruxolitinib. The patient experienced near‐complete clearance after three months, suggesting that topical JAK inhibition may be an effective and well‐tolerated option for refractory porokeratosis.
Joe Khodeir, Paul Ohanian, Marielena Ohanian   +2 more
wiley   +1 more source

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, Volume 177, Issue 4, Page 736-748, April 2026.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Applicability of Novel Laser Scanning Microscopy Techniques in Demonstrating Characteristic Features of Porokeratosis: In Vivo and Ex Vivo Investigation

JEADV Clinical Practice, Volume 5, Issue 1, Page 91-100, March 2026.
Porokeratoses, used here as an example of keratinization disorders, are marked by cornoid lamella and linked to skin cancer risk, making accurate diagnosis essential. This study compared conventional methods, dermoscopy, and histopathology, with advanced imaging using reflectance confocal microscopy (RCM) and multiphoton microscopy (MPM).
Rahime Inci, Noora Neittaanmäki, Jeemol James, Marica B. Ericson, Sirkku Peltonen, Despoina Kantere   +5 more
wiley   +1 more source