Results 101 to 110 of about 8,645,321 (278)

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

On the modified beta approximating operators of second kind

Journal of Numerical Analysis and Approximation Theory, 2005
We shall define a general linear operator from which we obtain as particular case the modified beta second kind operator\[(T_{p,q}f)(x)=\frac{1}{B(p,q)}\int_0^\infty\tfrac{u^{p-1}}{(1+u)^{p+q}}f\left(\frac{B(p,q)}{B(p+a,q-a)}u^ax\right){\rm d}u.\] We ...
Vasile Miheşan
doaj   +2 more sources

Approximation Properties of the Strong Difference Operators

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
    In this paper , we study some approximation  properties of the strong difference and study the relation between the strong difference and the weighted modulus of ...
S. K. Al-Saidy, A. A. Hamood
doaj  

Preserving properties of some Szasz-Mirakyan type operators

Journal of Numerical Analysis and Approximation Theory
For a family of Szasz-Mirakyan type operators we prove that they preserve convex-type functions and that a monotonicity property verified by Cheney and Sharma in the case Szasz-Mirakyan operators holds for the variation study here.
Jorge Bustamante
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Control Theory for a Class of 2D Continuous-Discrete Linear Systems

, 2004
This paper considers a general class of 2D continuous-discrete linear systems of both systems theoretic and applications interest. The focus is on the development of a comprehensive control systems theory for members of this class in a unified manner ...
Owens, D H, Rogers, E, Dymkov, M, Gaishun, I, Galkowski, K   +4 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source