Results 141 to 150 of about 3,786,566 (280)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A linear programming framework for optimizing molecular combinations of asphalt four components. [PDF]

Sci Rep
Zhu J, Wen C, Tao S.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Optimizing nutritionally adequate food basket using linear programming in Niayes Households, Senegal. [PDF]

PLoS One
Willane CT, Sylla PMDD, Thiam M, Ndiaye BM, Tall L, Idohou-Dossou N, Diouf A.   +6 more
europepmc   +1 more source

A safety framework for flow decomposition problems via integer linear programming. [PDF]

Bioinformatics, 2023
Dias FHC, Cáceres M, Williams L, Mumey B, Tomescu AI.   +4 more
europepmc   +1 more source

MULTIPLE OPTIMAL SOLUTIONS IN QUADRATIC PROGRAMMING MODELS [PDF]

The problem of determining whether quadratic programming models possess either unique or multiple optimal solutions is important for empirical analyses which use a mathematical programming framework.
Paris, Quirino
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

An approach based on linear programming to build experimentally driven pump-leak models. [PDF]

Biophys J
Catacuzzeno L, Cavaliere MG, Michelucci A.   +2 more
europepmc   +1 more source

Outlier detection based on Linear programming

, 2012
Outlier detection is an important step in many data-mining applications. In this paper, we propose an outlier detection mathod based on Linear Programming. The essential idea behind this technique is that two neighbor data points must be normal points or
Gao EY(高恩阳), Deng HB(邓华波), Wang TR(王天然), Liu WJ(刘伟军)   +3 more
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source