Results 91 to 100 of about 10,735,998 (316)

Ellipsoid Method for Linear Regression Parameters Determination

Кібернетика та комп'ютерні технології, 2020
Introduction. Linear regression parameters determination can be formulated as a non-smooth function minimization problem, which is Lp-norm of residual of the linear equations system.
V. Stovba
doaj   +1 more source

Predictive and mechanistic multivariate linear regression models for reaction development

Chemical Science, 2018
The utilization of physical organic molecular descriptors for the quantitative description of reaction outcomes in multivariate linear regression models is demonstrated as an effective tool for a priori prediction and mechanistic interrogation.
Celine B. Santiago, J. Guo, M. Sigman
semanticscholar   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Privacy-Preserving Distributed Linear Regression on High-Dimensional Data

Proceedings on Privacy Enhancing Technologies, 2017
We propose privacy-preserving protocols for computing linear regression models, in the setting where the training dataset is vertically distributed among several parties.
A. Gascón, Phillipp Schoppmann, Borja Balle, Mariana Raykova, Jack Doerner, Samee Zahur, David Evans   +6 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Piecewise Linear Regression Based on Plane Clustering

IEEE Access, 2019
Piecewise linear regressions have shown many successful applications in image denoising, signal process, and data mining fields. In essence, they attempt to seek multiple linear functions (piecewise/stepwise function) to fit the given scatter data points
Xubing Yang, Hongxin Yang, Fuquan Zhang, Li Zhang, Xijian Fan, Qiaolin Ye, Liyong Fu   +6 more
doaj   +1 more source

Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression

Genome Biology, 2019
Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects.
Christoph Hafemeister, R. Satija
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Linear and Non-Linear Regression: Powerful and Very Important Forecasting Methods [PDF]

Expert Journal of Business and Management, 2015
Regression Analysis is at the center of almost every Forecasting technique, yet few people are comfortable with the Regression methodology. We hope to improve the level of comfort with this article.
Athanasios VASILOPOULOS
doaj