Results 91 to 100 of about 1,688,491 (311)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
"A regression error specification test (RESET) for generalized linear models". [PDF]
Generalized linear models (GLMs) are generalizations of linear regression models, which allow fitting regression models to response data that follow a general exponential family.
Sunil Sapra
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Optimal designs for testing the functional form of a regression via nonparametric estimation techniques [PDF]
, 2000 For the problem of checking linearity in a heteroscedastic nonparametric regression model under a fixed design assumption we study maximin designs which maximize the minimum power of a nonparametric test over a broad class of alternatives from the ...
Stefanie Biedermann +3 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Partial Linear Quantile Regression and Bootstrap Confidence Bands [PDF]
In this paper uniform confidence bands are constructed for nonparametric quantile estimates of regression functions. The method is based on the bootstrap, where resampling is done from a suitably estimated empirical density function (edf) for residuals ...
Wolfgang Karl Härdle +2 more
core
ON THE GASTALDI – D’URSO FUZZY LINEAR REGRESSION [PDF]
Challenges of the Knowledge Society, 2011 In the crisp regression models, the differences between observed values and calculates ones are suspected to be caused by random distributed errors, although these are due to observation errors and an unappropriate model structure.
DANA-FLORENTA SIMION +2 more
doaj
Fast Censored Linear Regression [PDF]
Scandinavian Journal of Statistics, 2013 ABSTRACTWeighted log‐rank estimating function has become a standard estimation method for the censored linear regression model, or the accelerated failure time model. Well established statistically, the estimator defined as a consistent root has, however, rather poor computational properties because the estimating function is neither continuous nor, in
openaire +3 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Structural Change Analysis in Linear Regression Model.
Revista de Matemática: Teoría y Aplicaciones, 2010 Assuming that the observations are from normal distribution we obtain de distribution of the maximum likelihood ratio test if there is a change in the parameters at an unknown time and we find the maximum likehood estimators of the time change too.
Blanca Rosa Pérez Salvador +1 more
doaj +1 more source