Results 71 to 80 of about 1,298,639 (263)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Piecewise Linear Regression Based on Plane Clustering
IEEE Access, 2019 Piecewise linear regressions have shown many successful applications in image denoising, signal process, and data mining fields. In essence, they attempt to seek multiple linear functions (piecewise/stepwise function) to fit the given scatter data points
Xubing Yang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Imputing missing values using cumulative linear regression
CAAI Transactions on Intelligence Technology, 2019 The concept of missing data is important to apply statistical methods on the dataset. Statisticians and researchers may end up to an inaccurate illation about the data if the missing data are not handled properly.
Samih M. Mostafa
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
ANALYSIS OF DISCRETE DATA USING LINEAR REGRESSION
Ecosistemas y Recursos Agropecuarios, 2014 Maximum likelihood estimates are obtained for a linear regressio model where the dependent variable is a linear transformation of mutinomially distributed random variables.
Robert J. Flowers
doaj +1 more source
Ellipsoid Method for Linear Regression Parameters Determination
Кібернетика та комп'ютерні технології, 2020 Introduction. Linear regression parameters determination can be formulated as a non-smooth function minimization problem, which is Lp-norm of residual of the linear equations system.
V. Stovba
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source