Results 91 to 100 of about 1,319,586 (359)
Bayesian Inference for Generalized Additive Regression based on Dynamic Models [PDF]
, 1998 We present a general approach for Bayesian inference via Markov chain Monte Carlo (MCMC) simulation in generalized additive, semiparametric and mixed models.
Fahrmeir, Ludwig, Lang, S.
core +2 more sources
IFAC Proceedings Volumes, 2009 We present a method for detecting changes and estimating parameters in AR(X) models. The method is based on the assumption of piecewise constant parameters resulting in a sparse structure of their ...
Salehpour, Soheil +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Environmental Health, 2020 Background Various risk factors influence obesity differently, and environmental endocrine disruption may increase the occurrence of obesity. However, most of the previous studies have considered only a unitary exposure or a set of similar exposures ...
Bangsheng Wu +3 more
doaj +1 more source
Geophysical Research Letters, 2023 Models assume that mixed‐phase clouds consist of uniformly mixed ice crystals and liquid cloud droplets when observations have shown that they consist of clusters, or “pockets,” of ice crystals and liquid cloud droplets.
Q. Coopman, I. Tan
doaj +1 more source
Generalized Functional Additive Mixed Models
, 2016 We propose a comprehensive framework for additive regression models for non-Gaussian functional responses, allowing for multiple (partially) nested or crossed functional random effects with flexible correlation structures for, e.g., spatial, temporal, or
Gertheiss, Jan +2 more
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Responsiveness of quality of life instruments : a thesis presented in partial fulfilment of the requirements for the degree of Master of Applied Statistics in Statistics at Massey University [PDF]
, 2001 Quality of life (QoL) is a phrase that is intuitively meaningful. As a concept it distinguishes between the mere duration of life and a life that is in some sense 'worthwhile'.
Weatherall, Mark
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source