Results 71 to 80 of about 12,232,356 (294)
Adaptive Partially Linear Regression Models by Mixing Different Estimates [PDF]
American Journal of Theoretical and Applied Statistics, 2019 This paper proposes adapting the semiparametric partial model (PLM) by mixing different estimation procedures defined under different conditions. Choosing an estimation method of PLM, from several estimation methods, is an important issue, which depends on the performance of the method and the properties of the resulting estimators.
openaire +1 more source
Mixed-effect linear regression candidate models.
, 2019 Mixed-effect linear regression candidate models.
Jason Parker (2050768) +9 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Methods in Ecology and EvolutionBiological data often violate the assumption of constant variance, yet such heteroscedasticity can reflect meaningful biological processes such as plasticity, canalization or stress responses. Despite this, most models treat variance as statistical noise.
Shinichi Nakagawa +6 more
doaj +1 more source
Effect of Decompression on Jaw Cystic Lesions Based on Three-Dimensional Volumetric Analysis
Medicina, 2020 Background and objectives: This study aimed to evaluate the effectiveness of decompression on jaw cysts according to various parameters by volumetric analysis using three-dimensional computed tomography.
Yeh-Jin Kwon +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
S-estimation and a robust conditional Akaike information criterion for linear mixed models. [PDF]
We study estimation and model selection on both the fixed and the random effects in the setting of linear mixed models using outlier robust S-estimators.
Tharmaratnam, Kukatharmini +1 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source