Results 61 to 70 of about 12,232,356 (294)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Insight into Genome-Wide Associations of Growth Trajectories Using a Hierarchical Non-Linear Mixed Model

Biology
In applying a hierarchical mixed model to genome-wide association analysis (GWAS) of longitudinal data, dimensionality reduction through modeling repeated measurements improves both computational efficiency and statistical power. Legendre polynomials can
Ying Zhang, Li’ang Yang, Weiguo Cui, Runqing Yang   +3 more
doaj   +1 more source

ESTIMATING ABOVEGROUND BIOMASS OF BAMBOO AND MIXED BAMBOO FOREST IN THUA THIEN-HUE PROVINCE, VIET NAM USING PALSAR-2 AND LANDSAT OLI DATA [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
In this study, above-ground biomass (AGB) performance was evaluated by PALSAR-2 L-band and Landsat data for bamboo and mixed bamboo forest. The linear regression model was chosen and validated for forest biomass estimation in A Luoi district, Thua Thien ...
T. T. Cat Tuong, T. T. Cat Tuong, H. Tani, X. F. Wang, V.-M. Pham   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Efficient Algorithms for Estimating the Parameters of Mixed Linear Regression Models

2025 IEEE 35th International Workshop on Machine Learning for Signal Processing (MLSP)
Mixed linear regression (MLR) model is among the most exemplary statistical tools for modeling non-linear distributions using a mixture of linear models. When the additive noise in MLR model is Gaussian, Expectation-Maximization (EM) algorithm is a widely-used algorithm for maximum likelihood estimation of MLR parameters.
Babak Barazandeh, Ali Ghafelebashi, Meisam Razaviyayn, Ram Sriharsha   +3 more
openaire   +3 more sources

Normal-Mixture-of-Inverse-Gamma Priors for Bayesian Regularization and Model Selection in Structured Additive Regression Models [PDF]

, 2010
In regression models with many potential predictors, choosing an appropriate subset of covariates and their interactions at the same time as determining whether linear or more flexible functional forms are required is a challenging and important task. We
Scheipl, Fabian
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Estimating biomass of mixed and uneven-aged forests using spectral data and a hybrid model combining regression trees and linear models

iForest - Biogeosciences and Forestry, 2016
The Sierra Madre Occidental mountain range (Durango, Mexico) is of great ecological interest because of the high degree of environmental heterogeneity in the area.
López-Serrano Pablito M, López-Sánchez Carlos A, Díaz-Varela Ramón A, Corral-Rivas José J, Solís-Moreno R, Vargas-Larreta B, Álvarez-González Juan G   +6 more
doaj   +1 more source

The association between urinary phthalate metabolites and serum thyroid function in US adolescents

Scientific Reports, 2023
The aim was to investigate the association between mixed exposure to phthalates and serum thyroid function among US adolescents. The study used 2007–2008 survey data from the National Health and Nutrition Examination Survey (NHANES).
Shi-ting Xiang, Yuhan Cao, Jie Dong, Chao Li, Jun Qiu, Xun Li   +5 more
doaj   +1 more source

Estimating Functional Linear Mixed-Effects Regression Models

, 2016
The functional linear model is a popular tool to investigate the relationship between a scalar/functional response variable and a scalar/functional covariate. We generalize this model to a functional linear mixed-effects model when repeated measurements are available on multiple subjects.
Liu, Baisen, Cao, Jiguo
openaire   +2 more sources