Results 81 to 90 of about 1,409,985 (359)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

ESTIMATING ABOVEGROUND BIOMASS OF BAMBOO AND MIXED BAMBOO FOREST IN THUA THIEN-HUE PROVINCE, VIET NAM USING PALSAR-2 AND LANDSAT OLI DATA [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
In this study, above-ground biomass (AGB) performance was evaluated by PALSAR-2 L-band and Landsat data for bamboo and mixed bamboo forest. The linear regression model was chosen and validated for forest biomass estimation in A Luoi district, Thua Thien ...
T. T. Cat Tuong   +4 more
doaj   +1 more source

Fence methods for mixed model selection

open access: yes, 2008
Many model search strategies involve trading off model fit with model complexity in a penalized goodness of fit measure. Asymptotic properties for these types of procedures in settings like linear regression and ARMA time series have been studied, but ...
Gu, Zhonghua   +3 more
core   +1 more source

A mixed effect model for bivariate meta-analysis of diagnostic test accuracy studies using a copula representation of the random effects distribution [PDF]

open access: yes, 2015
Diagnostic test accuracy studies typically report the number of true positives, false positives, true negatives and false negatives. There usually exists a negative association between the number of true positives and true negatives, because studies that
Arends   +51 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Effect of Decompression on Jaw Cystic Lesions Based on Three-Dimensional Volumetric Analysis

open access: yesMedicina, 2020
Background and objectives: This study aimed to evaluate the effectiveness of decompression on jaw cysts according to various parameters by volumetric analysis using three-dimensional computed tomography.
Yeh-Jin Kwon   +7 more
doaj   +1 more source

Understanding Mixed-Effects Models Through Data Simulation

open access: yesAdvances in Methods and Practices in Psychological Science, 2021
Experimental designs that sample both subjects and stimuli from a larger population need to account for random effects of both subjects and stimuli using mixed-effects models.
Lisa M. DeBruine, Dale J. Barr
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Enhancing Cardiovascular Risk Prediction: Development of an Advanced Xgboost Model with Hospital-Level Random Effects

open access: yesBioengineering
Background: Ensemble tree-based models such as Xgboost are highly prognostic in cardiovascular medicine, as measured by the Clinical Effectiveness Metric (CEM). However, their ability to handle correlated data, such as hospital-level effects, is limited.
Tim Dong   +8 more
doaj   +1 more source

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